Results 41 to 50 of about 74,632 (268)

Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants

Advanced Science, EarlyView.
Differences in timing (ΔT) are weighted heavily compared to differences in loudness (ΔL) in binaural hearing with cochlear implants. Abstract Normally hearing humans can localize sound sources quite accurately, with minimum audible angles as small as 1°. To achieve this, these auditory pathways combine information from multiple acoustic cues, including
Sarah Buchholz, Susan Arndt, Jan W. H. Schnupp, Nicole Rosskothen‐Kuhl   +3 more
wiley   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Incidence of Otolaryngological Manifestations in Individuals with Autism Spectrum Disorder: A Special Focus on Auditory Disorders

Audiology Research
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by stereotyped and repetitive behavior patterns. In addition to neurological and behavioral problems, individuals with ASD commonly experience otolaryngological comorbidities ...
Keelin McKenna, Soumil Prasad, Jaimee Cooper, Ava M. King, Shahriar Shahzeidi, Jeenu Mittal, Max Zalta, Rahul Mittal, Adrien A. Eshraghi   +8 more
doaj   +1 more source

Impact of the COVID-19 Pandemic on Cochlear Implant Usage in Children. [PDF]

Otolaryngol Head Neck Surg
Abstract Objective To evaluate the impact of the COVID‐19 pandemic on cochlear implant (CI) usage in children by comparing hearing hour percentage (HHP) during the pandemic to prepandemic levels. Study Design Retrospective Cohort Study. Setting Primary Children's Hospital, Utah.
Kfoury P, Tonkovich K, Jeon EK, Stout JC, Christensen H, Reddy MD, Firpo MA, Park AH.   +7 more
europepmc   +2 more sources

Verbal Learning and Memory After Cochlear Implantation in Postlingually Deaf Adults: Some New Findings with the CVLT-II [PDF]

, 2018
OBJECTIVES: Despite the importance of verbal learning and memory in speech and language processing, this domain of cognitive functioning has been virtually ignored in clinical studies of hearing loss and cochlear implants in both adults and children ...
Boyce, Lauren, Broadstock, Arthur, Castellanos, Irina, Davies, Alexandra, Harris, Michael S., Hernandez, Luis R., Kronenberger, William G., Miller, Kelly, Moberly, Aaron C., Pisoni, David B., Safdar, Natalie, Vasil, Kara, Wucinich, Taylor, Xu, Huiping   +13 more
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Congenitally deaf children's care trajectories in the context of universal neonatal hearing screening: a qualitative study of the parental experiences [PDF]

, 2011
The objective of this study is to examine the early care trajectories of congenitally deaf children from a parental perspective, starting with universal neonatal hearing screenings.
Desnerck, Greetje, Hardonck, Stefan, Loots, Gerrit, Louckx, Fred, Sigurjonsdottir, Hanna Bjorg, Van Hove, Geert, Vankerschaver, Erwin, Vanroelen, Christophe   +7 more
core   +2 more sources

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

Drug Delivery, 2018
Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need.
Ao Li, Dan You, Wenyan Li, Yingjie Cui, Yingzi He, Wen Li, Yan Chen, Xiao Feng, Shan Sun, Renjie Chai, Huawei Li   +10 more
doaj   +1 more source

Neuro-electronic technology in medicine and beyond [PDF]

, 2000
This dissertation looks at the technology and social issues involved with interfacing electronics directly to the human nervous system, in particular the methods for both reading and stimulating nerves.
Ward, Jamie A
core