Results 81 to 90 of about 1,083,423 (403)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Clinical evaluation of the Nucleus® 6 cochlear implant system: Performance improvements with SmartSound iQ

International Journal of Audiology, 2014
Objective: This paper provides a detailed description of the Nucleus 6 system, and clinically evaluates user performance compared to the previous Nucleus 5 system in cochlear implant recipients.
Stefan J. Mauger, Chris Warren, M. Knight, Michael Goorevich, Esti Nel   +4 more
semanticscholar   +1 more source

Deaf children need language, not (just) speech [PDF]

, 2019
Deaf and Hard of Hearing (DHH) children need to master at least one language (spoken or signed) to reach their full potential. Providing access to a natural sign language supports this goal.
Caselli, Naomi, Hall, Matthew, Hall, Wyatte   +2 more
core   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Applications of pre- and intraoperative eAEP like eABR in cochlear implant candidacy

Current Directions in Biomedical Engineering
Introduction: Preoperative electrically auditory evoked potentials (= eAEP, i.e., eABR for brainstem, eAMLR for midbrain, and eALR for cortex) can be performed under local anesthesia, achieving subjective sensation and hearing in patients having a ...
Polterauer Daniel, Neuling Maike, Mandruzzato Giacomo, Polak Marek, Müller Joachim, Hempel John-Martin   +5 more
doaj   +1 more source

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

Neural Plasticity, 2018
Sudden sensorineural hearing loss (SSHL) is a clinically common acute symptom in otolaryngology. Although the incidence of SSHL has increased around the world in recent years, the etiology of the disease is still unclear.
Guangfei Li, Dan You, Jiaoyao Ma, Wen Li, Huawei Li, Shan Sun   +5 more
doaj   +1 more source

CORRELATION BETWEEN NEURAL RESPONSE TELEMETRY (NRT) MESUREMENT LEVEL AND BEHAVIORL (T-LEVEL AND C-LEVEL) IN PRELINGUAL COCHLEAR IMPLANT PATIENTS [PDF]

, 2013
 Objectives: To study the correlation between Neural Response Telemetry (NRT) measurement level and behavioral (Threshold level and Comfort level) in pre lingual cochlear implant patients age between 2 -10 years old at one and three months post implant ...
ABDULLAH, ASMA BINTI, HASHIM, WAN FAZLINA, KASIM, KASIM S.   +2 more
core   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Therapeutic approach to pediatric acute mastoiditis – an update

Brazilian Journal of Otorhinolaryngology, 2019
Introduction: Acute mastoiditis remains the most common complication of acute otitis media. It may rarely appear also in cochlear implant patients. However, the treatment recommendations for this disease are not precisely defined or employed, and in the ...
Józef Mierzwiński, Justyna Tyra, Karolina Haber, Maria Drela, Dariusz Paczkowski, Michael David Puricelli, Anna Sinkiewicz   +6 more
doaj