Results 251 to 260 of about 1,069,962 (387)

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Long-Term Hearing Outcomes Following Cochlear Implantation in Far Advanced Otosclerosis. [PDF]

Otolaryngol Head Neck Surg
Quatre R, Eklöf M, Wales J, Bonnard Å.
europepmc   +1 more source

Cochlear Implants in the Geriatric Population: Benefits Outweigh Risks

, 1999
Craig A. Buchman, Michael J. Fucci, William M. Luxford   +2 more
openalex   +1 more source

Ototoxicity in Cancer Therapies

Oral Diseases, EarlyView.
Sady Selaimen da Costa, Nathaniel S. Treister, Caio Eddie de Melo Alves   +2 more
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Timing of cochlear implantation in large vestibular aqueduct syndrome-a retrospective cohort analysis. [PDF]

Front Neurol
Liu X, Huang W, Wang Y, Xu J, Xie L, Liu L, Chen J.   +6 more
europepmc   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

The Prognostic Value Preoperative Promontory Testing in Japanese Cochlear Implant Patients.

, 1999
Naomi Sugiyama, Kazuteru Doi, Takako Iwaki, Kōichi Yamamoto, Takayuki Kawashima, Takeshi Kubo   +5 more
openalex   +2 more sources

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Access to Cochlear Implantation: Trends in Surgeon Volume and Training. [PDF]

Laryngoscope
Espahbodi M, Trautwein P, Bestourous DE, Zwolan TA, Nassiri AM, Carlson ML, Erbele ID, Patel NS, Gurgel RK.   +8 more
europepmc   +1 more source