Results 171 to 180 of about 356,855 (261)

A phage cocktail with bactericidal and virulence-attenuating effects against dairy-associated hypervirulent <i>Klebsiella pneumoniae</i>. [PDF]

Curr Res Food Sci
Ji X, Wang J, García P, Li J, Zhang L, Wang R, He T.   +6 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Tumor-specific antibody cocktail treatment suppresses colorectal tumor growth in mice. [PDF]

Cancer Immunol Immunother
Shukla GS, Pero SC, Sun Y, Mei L, Barrantes-Reynolds R, Fournier MR, Ackerman ME, Krag DN.   +7 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Synergistic effects of halo-plaque forming phage cocktails against polymicrobial <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i>. [PDF]

Microbiol Spectr
Naknaen A, Rueangrit A, Sudhikaran W, Chukamnerd A, Chumtong S, Chusri S, Pomwised R, Surachat K, Singkhamanan K, Ngasaman R.   +9 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Exploring the Combined Effect of Bm86 and Subolesin Polypeptide Vaccines in Cattle Naturally Infested with <i>Rhipicephalus microplus</i>. [PDF]

Vet Sci
Mendoza-Martínez N, Alonso-Díaz MÁ, Merino-Charrez JO, Lagunes-Quintanilla R.   +3 more
europepmc   +1 more source

Heterostructured Materials for Room‐Temperature Na‐S Batteries: Directional Design Strategies and Multifaceted Applications

Advanced Science, EarlyView.
In this work, heterostructured materials for room‐temperature Na‐S batteries are comprehensively reviewed. The electrochemical mechanisms of Na‐S batteries based on various redox pathways are clarified. The intrinsic functionalities and design principles of heterostructured materials are summarized.
Yeqing Yang, Xue Li, Kunjie Zhu, Xiang‐Long Huang, Yun‐Xiao Wang   +4 more
wiley   +1 more source

The cocktail method: influence of microbubble shell homogeneity on acoustic behavior and stability.

Soft Matter
Poc P, Guerriero G, Büchler J, Grossrieder T, Cattaneo M, Collado-Lara G, Blanken N, Oberhuber I, Kusch J, Supponen O, Schuerle S.   +10 more
europepmc   +1 more source

Phage Cocktail Designed for Wastewater Bioremediation Has Limited Effect on Crustacean Filtrator Microbiome Diversity and Health. [PDF]

Environ Microbiol Rep
Grabska M, Gorecki A, Pye HV, Adriaenssens EM, Grzesiuk M.   +4 more
europepmc   +1 more source