Results 121 to 130 of about 149,027 (258)

Sitting Less, Moving More: A Compositional Data Analysis of Movement Behaviours and Adolescent Health‐Related Quality of Life

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim To predict changes in health‐related quality of life (HRQoL) when sedentary behaviour was hypothetically replaced with other movement behaviours (sleep, standing, light physical activity and moderate‐to‐vigorous physical activity) in adolescents.
Deborah M. Telford   +2 more
wiley   +1 more source

Bayesian inference for dynamic Q matrices and attribute trajectories in hidden Markov diagnostic classification models

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Hidden Markov diagnostic classification models capture how students' cognitive attributes evolve over time. This paper introduces a Bayesian Markov chain Monte Carlo algorithm for diagnostic classification models that jointly estimates time‐varying Q matrices, latent attributes, item parameters, attribute class proportions and transition ...
Chen‐Wei Liu
wiley   +1 more source

Aquisição da coda simples e complexa com /S/ em crianças com desvio fonológico The acquisition of simple and complex coda /S/ in children with phonological disorder

open access: yesRevista CEFAC, 2013
OBJETIVO: descrever a produção das codas finais simples e complexa com /S/ em crianças com desvio fonológico e verificar a influência de variáveis linguísticas e extralinguísticas na aquisição das mesmas.
Carolina Lisbôa Mezzomo   +4 more
doaj  

To vary or not to vary: A flexible empirical Bayes factor for testing variance components

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Random effects are the gold standard for capturing structural heterogeneity, such as individual differences or temporal dependence. Yet testing their presence is difficult because variance components are constrained to be non‐negative, creating a boundary problem. This paper introduces a flexible empirical Bayes factor (EBF) for testing random
Fabio Vieira, Hongwei Zhao, Joris Mulder
wiley   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

open access: yesBritish Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva   +10 more
wiley   +1 more source

Acquisition of complex coda and sonority among selected bilingual Nigerian children

open access: yesJournal of Child Language Acquisition and Development, 2020
This study examined the role of sonority in the acquisition of complex coda by Yoruba-English bilingual children with a view to determining the way children rank constraints to arrive at their outputs.
Grace Boluwatife Olarewaju   +1 more
doaj  

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić   +25 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci   +15 more
wiley   +1 more source

Exploring the Impact of RNU4‐2 Defects on Neurodevelopmental Disorders in a Korean Population

open access: yesClinical Genetics, EarlyView.
Among 15 450 Korean individuals, noncoding RNU4‐2 variants, primarily the recurrent de novo n.64_65insT, make up 0.72% of neurodevelopmental disorders. Modeling and RNA‐seq suggest U4/U6 disruption and abnormal 5′ splice‐site selection, supporting routine use of WGS analysis for reanalyzing unresolved cases. ABSTRACT Neurodevelopmental disorders (NDDs)
Juhyeon Hong   +20 more
wiley   +1 more source

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