Results 31 to 40 of about 428,859 (217)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Computer ScienceIntroductionMobile applications have become indispensable in our daily lives. However, mobile application development faces several challenges, including limited resources, budget, and time to market.
Haroon Zafar +3 more
doaj +1 more source
Analysis of the Code Quality of Code Automatic Generation Tool Github Copilot [PDF]
Jisuanji kexueGithub Copilot is a generative AI-based code auto-generation tool launched by Github and OpenAI in 2022.One of its core functions is to generate corresponding implementation code based on natural language annotations describing functions.This expansion ...
WANG Dongyu, MO Ran, ZHAN Wenjing, JIANG Yingjie
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
CGGNet: Compiler-Guided Generation Network for Smart Contract Data Augmentation
IEEE AccessThe emergence of blockchain and smart contracts has revolutionized various industries by enabling automated code execution. However, the development of smart contracts, rooted in programming languages, inherits common challenges in traditional software ...
Seon-Jin Hwang +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Prompt Learning Based Parameter-efficient Code Generation [PDF]
Jisuanji kexueAutomatic code generation is one of the effective ways to improve the efficiency of software development.Existing research often regards code generation as a sequence-to-sequence task,and the process of fine-tuning of large-scale pre-trained language ...
XU Yiran, ZHOU Yu
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source