Results 51 to 60 of about 107,111 (311)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

CodemixedNLP: An Extensible and Open NLP Toolkit for Code-Mixing [PDF]

open access: gold, 2021
Sai Muralidhar Jayanthi   +3 more
openalex   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

AN ANALYSIS OF CODE MIXING IN A DEBATE ACTIVITY AS PART OF ENGLISH CLUB PROGRAMS AT SMAN 2 BENGKULU CITY

open access: yesJournal of English Education and Teaching, 2018
The aim of this research is to investigate code mixing produced by the students of ‘Debate Activity as part of English Club’ program at SMAN 2 Bengkulu city. The design are descriptive quantitative and qualitative.
Darpeli Eli Zetri   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Subtitling Hong Kong Code-Mixing and Code-Switching

open access: yesExchanges
Translation has largely been considered a process involving only two languages, source and target. However, plurilingual audiovisual content has proliferated over the last few decades, reflecting, as a result, the world’s linguistic intermingling.
Luis Damián Moreno García
doaj   +1 more source

CODE SWITCHING AND CODE MIXING IN TOURISM INDUSTRY TOWARD MULTILINGUAL

open access: yesScript Journal, 2016
Asian Economics Community ( MEA ) has big influence for everyone in the world. This agreement will attract more and more people from other countries to come, stay dan work in Indonesia. Therefore, people need to communicate with more than one language
yogi setia samsi
doaj   +1 more source

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