Results 101 to 110 of about 198,004 (302)
Frontiers in Cellular Neuroscience, 2017 A major stumbling block to cracking the real-time neural code is neuronal variability - neurons discharge spikes with enormous variability not only across trials within the same experiments but also in resting states.
Meng Li +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2014 This project is going help students wanting to learn about sets and set theory. A language made up by me will be read by an interpreter, which will be needed to drive the program.
Singer, Graham, `14
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
C source code obfuscator [PDF]
, 2012 summary:Obfuscation is a process that changes the code, but without any change to semantics. This process can be done on two levels. On the binary code level, where the instructions or control flow are modified, or on the source code level, where we can ...
Kolář, Dušan, Ďurfina, Lukáš
core
Mother tongue policies and mathematical terminology in the teaching of mathematics
Pythagoras, 2008 The Department of Education in South Africa advocates collaborative and constructivist learning; however, observations indicate that little discussion occurs in most multilingual mathematics classes.
Mercy Kazima
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Cell StressDifferential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic ...
Yiguo Zhang +8 more
doaj +1 more source
Models and Algorithms for Estimation and Minimization of the Risks Associated with Dredging
Transport and Telecommunication, 2017 There are a lot of models and algorithms to minimize risks during dredging operations and they are not without drawbacks. The paper describes the authors’ approach to solving this problem.
Mamunts D. +5 more
doaj +1 more source