Results 51 to 60 of about 4,310,333 (286)

Are code smell detection tools suitable for detecting architecture degradation?

open access: yes, 2017
Context: Several studies suggest that there is a relation between code smells and architecture degradation. They claim that classes, which have degraded architecture-wise, can be detected on the basis of code smells, at least if these are manually ...
Sebastian Herold   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Code Smell Detection using Features from Version History

open access: yes, 2023
Code smells are indicators for bad quality of source code. A well suited approach for the development of a smell detector are machine learning techniques that learn based on features, i.e., measurable properties of the software under investigation, e.g.,
Engeln, Ulrike
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

A Novel Four-Way Approach Designed With Ensemble Feature Selection for Code Smell Detection

open access: yesIEEE Access, 2021
Purpose: Code smells are residuals of technical debt induced by the developers. They hinder evolution, adaptability and maintenance of the software. Meanwhile, they are very beneficial in indicating the loopholes of problems and bugs in the software ...
Inderpreet Kaur, Arvinder Kaur
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

THE SEMANTIC ANALYSIS OF ‘SMELL’ TERMS IN JAVANESE [PDF]

open access: yes, 2010
Semantic field of a word varies in every language since it is influenced by the culture where people originally come from. Javanese people have various terms in expressing smell. They differentiate each term based on what the object that causes smell is.
SEPTIAWATI, RENY PUTRI
core   +1 more source

Fine-Tuning UniXcoder for Code Smell Detection in Java Projects

open access: yesIEEE Access
Code smells are symptoms of poor software design that hinder maintainability and increase technical debt interest. Automated detection of code smells is crucial in software development industry, where manual inspection is costly and error-prone. Although
Hanson Prihantoro Putro   +4 more
doaj   +1 more source

DECOR: A Method for the Specification and Detection of Code and Design Smells [PDF]

open access: yesIEEE Transactions on Software Engineering, 2010
Code and design smells are poor solutions to recurring implementation and design problems. They may hinder the evolution of a system by making it hard for software engineers to carry out changes. We propose three contributions to the research field related to code and design smells: (1) DECOR, a method that embodies and defines all the steps necessary ...
Moha, Naouel   +3 more
openaire   +3 more sources

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

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