Results 81 to 90 of about 173,690,188 (293)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

“I don’t Care that People don’t Like What I Do” – Business Codes Viewed as Invisible or Visible Restrictions

open access: yes, 2009
Research about codes of corporate ethics has hitherto taken a hypothetical, correct meaning of codes for granted. The article problematises the dichotomous categories intrinsic and subjective meanings of codes.
Peter Norberg, Norberg, Peter,
core   +1 more source

Achieving cultural safety for Australia's First Peoples: a review of the Australian Health Practitioner Regulation Agency-registered health practitioners' Codes of Conduct and Codes of Ethics

open access: yes, 2021
Objective: Health practitioners' Codes of Conduct and Codes of Ethics articulate practice standards across multiple domains, including the domain of cultural safety.
Hall, Kerry   +15 more
core   +1 more source

Quality of Publication Ethics in the Instructions to the Authors of Iranian Journals of Medical Sciences

open access: yesIranian Journal of Medical Sciences, 2013
Providing a perfect instruction to authors can prevent most potential publication ethics errors. This study was conducted to determine the quality of ethical considerations in the instructions to the authors of Iranian research scientific journals of ...
Fatemeh Salamat   +2 more
doaj  

Código de Ética Médica brasileiro: limites deontológicos e bioéticos

open access: yesRevista Bioética
Resumo A evolução tecnocientífica tem imposto desafios à sociedade e, particularmente, à medicina. Mudanças sociais nas relações médico-paciente e entre profissionais da saúde demandam novas formas de regulação dessas relações.
Francisco José Passos Soares   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Controle ético de pesquisas cujos resultados tenham alto risco para a saúde da população

open access: yesSaúde em Debate
RESUMO Este artigo problematiza o conflito ético surgido entre a necessidade de garantir o avanço da ciência e controlar suas possíveis consequências para a humanidade. Em pesquisa realizada na literatura científica latino-americana e nas bases jurídicas
Sandra Ceciliano de Souza Veloso   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Brazilian Society of Nephrology Code of Conduct: a bioethical analysis

open access: yesBrazilian Journal of Nephrology
Introduction: Professional deontology can be defined as a set of principles, values and rules of conduct to be applied in the exercise of functions and inherent to a given profession.
Fábio Humberto Ribeiro Paes Ferraz   +1 more
doaj   +2 more sources

The code of ethics for nurses.

open access: yesIranian journal of public health, 2013
Nurses are ever-increasingly confronted with complex concerns in their practice. Codes of ethics are fundamental guidance for nursing as many other professions. Although there are authentic international codes of ethics for nurses, the national code would be the additional assistance provided for clinical nurses in their complex roles in care of ...
B Larijani   +10 more
openaire   +3 more sources

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