Results 181 to 190 of about 241,954 (329)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Diverging regulatory DNA in adaptive medical AI: US agility and EU accountability in lifecycle governance. [PDF]

Front Med (Lausanne)
Lee JH, Choi B, Jeong K, Suh SW, Rhee H, Kim JH, Son DS.   +6 more
europepmc   +1 more source

Unveiling the temporally contingent role of codification in alliance success

, 2015
K. Heimeriks, Christopher B. Bingham, T. Laamanen   +2 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mortality incidence in spondyloarthritis: real-world evidence using the TriNetX Global Collaborative Network. [PDF]

RMD Open
Llop M, Rodrigo-Parés A, Saus E, Moreno M, Arévalo M, Cabanillas M, Gratacós J, Calvet J.   +7 more
europepmc   +1 more source

On the Legal Method of the Uniform Commercial Code [PDF]

, 1951
Franklin, Mitchell
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Society for Maternal-Fetal Special Statement: Transforming the maternity care team model. [PDF]

Pregnancy (Hoboken)
Society for Maternal-Fetal Medicine (SMFM), Gaur P, Goulding AN, Spong CY, Werner EF, SMFM Health Policy and Advocacy Committee.   +5 more
europepmc   +1 more source

The Proposed Uniform Commercial Code As a Problem in Codification [PDF]

, 1951
Beutel, Frederick K.
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source