Results 171 to 180 of about 1,765,355 (377)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Applying Grounded Theory to Conceptual Data Modeling: Effects of Constant Comparative Method [PDF]

, 2011
This article presents an experimental design and the pilot experiment results of applying grounded theory to conceptual datamodeling. The objective of this study is to develop a procedural method for concept discovery, which is essential in datamodeling.
Kim, Taekyung, Park, Jinsoo, Rho, Sangkyu   +2 more
core   +1 more source

"Meaning" as a sociological concept: A review of the modeling, mapping, and simulation of the communication of knowledge and meaning

, 2011
The development of discursive knowledge presumes the communication of meaning as analytically different from the communication of information. Knowledge can then be considered as a meaning which makes a difference.
Abramson N, Ahlgren P, Ashby WR, Bateson G, Boudon R, Bourdieu P, Bourdieu P, Dasgupta P, Derrida J, Dubois DM, Dubois DM, Edelman GM, Epstein JM, Foray D, Foucault M, Fruchterman T, Fuchs P, Garner WR, Giddens A, Giddens A, Habermas J, Habermas J, Habermas J, Heidegger M, Hesse M, Husserl E, Husserl E, Krippendorff K, Kuhn TS, Latour B, Law J, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Leydesdorff L, Loet Leydesdorff, Lucio-Arias D, Lucio-Arias D, Luhmann N, Luhmann N, Luhmann N, Luhmann N, Luhmann N, Luhmann N, Marx K, Maturana HR, Maturana HR, McGill WJ, McLuhan M, Mead GH, Merton RK, Montesquieu, Nietzsche F, Parsons T, Parsons T, Pask G, Priestley J, Rosen R, Salton G, Schütz A, Schütz A, Shannon CE, Simon HA, Theil H, Ulanowicz RE, Von Foerster H, Weaver W, Weinstein F, Whitley RD, Wittgenstein L, Yeung RW   +80 more
core   +1 more source

The Risks of Using Large Language Models for Text Annotation in Social Science Research [PDF]

arXiv
Generative artificial intelligence (GenAI) or large language models (LLMs) have the potential to revolutionize computational social science, particularly in automated textual analysis. In this paper, we conduct a systematic evaluation of the promises and risks of using LLMs for diverse coding tasks, with social movement studies serving as a case ...
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

A tutorial for integrating generative AI in mixed methods data analysis

Discover Education
The current article used real data to demonstrate the analysis and synthesis of Mixed Methods Research (MMR) data with generative Artificial Intelligence (Gen AI). I explore how reliable and valid Gen AI data outputs are and how to improve their use. The
Celeste Combrinck
doaj   +1 more source

Introduction: Scientific Explanation Beyond Causation [PDF]

, 2017
This is an introduction to the volume "Explanation Beyond Causation: Philosophical Perspectives on Non-Causal Explanations", edited by A. Reutlinger and J. Saatsi (OUP, forthcoming in 2017).
Reutlinger, Alexander, Saatsi, Juha
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source