Results 161 to 170 of about 10,370 (207)
Some of the next articles are maybe not open access.
On the Probability of Codon−Codon Mutational Replacements
Journal of Chemical Information and Computer Sciences, 1997The content of the data base of blocks of protein sequences (Henikoff, S. ; Henikoff, J. G. Genomics 1994, 19, 97−107) were used in order to locate the homologous gene sequences. Aligning these sequences the 64 × 64 matrix of codon−codon interchanges was constructed. Matrices were generated for various phylogenetical groups of organisms and for various
Danilo Pumpernik +2 more
openaire +1 more source
Codon reassignment (codon capture) in evolution
Journal of Molecular Evolution, 1989The genetic code, once thought to be "frozen," shows variations from the universal code. Variations are found in mitochondria, Mycoplasma, and ciliated protozoa. The variations result from reassignment of codons, especially stop codons. The reassignments take place by disappearance of a codon from coding sequences, followed by its reappearance in a new
S, Osawa, T H, Jukes
openaire +2 more sources
Journal of Molecular Evolution, 1995
Schultz and Yarus (J. Mol. Biol. 235:1377-1380, 1994) have proposed that reassignment of codons in the genetic code passes through a stage in which the codons are ambiguously translated. In contrast we state that such ambiguity would be deleterious, and that, to be reassigned, a codon, together with the tRNA that translates the codon, must first ...
S, Osawa, T H, Jukes
openaire +2 more sources
Schultz and Yarus (J. Mol. Biol. 235:1377-1380, 1994) have proposed that reassignment of codons in the genetic code passes through a stage in which the codons are ambiguously translated. In contrast we state that such ambiguity would be deleterious, and that, to be reassigned, a codon, together with the tRNA that translates the codon, must first ...
S, Osawa, T H, Jukes
openaire +2 more sources
Experientia, 1990
The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide doublet preference, seen also in non-coding sequences and thought to arise from the dependence of mutational events on surrounding sequence.
openaire +2 more sources
The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide doublet preference, seen also in non-coding sequences and thought to arise from the dependence of mutational events on surrounding sequence.
openaire +2 more sources
Origins of life and evolution of the biosphere, 1999
Several hypotheses on the origin of codon assignments imply that the present protein synthesizing machinery was already in place when the assignments were made. These are examined by computer modeling. The results do not suggest that assignments were optimized for resistance to reading and mutation errors, nor that the assignments are random.
openaire +2 more sources
Several hypotheses on the origin of codon assignments imply that the present protein synthesizing machinery was already in place when the assignments were made. These are examined by computer modeling. The results do not suggest that assignments were optimized for resistance to reading and mutation errors, nor that the assignments are random.
openaire +2 more sources
Codon optimizer: a freeware tool for codon optimization
Protein Expression and Purification, 2003Selection plays a major role in the determination of codon usage in all organisms studied so far. In highly expressed genes, a narrow set of codons is used and these codons correspond to the more abundant tRNA species. This minimizes the risk of tRNA depletion during translation.
openaire +2 more sources
An effect of codon context on the mistranslation of UGU codons in vitro
Journal of Molecular Biology, 1984Effects of codon context on nonsense codon suppression may act either through release factor recognition of termination codons or aminoacyl-tRNA selection by the ribosome. The latter hypothesis has been studied by comparing misreading by Escherichia coli UGA suppressor tryptophan tRNA of UGU (cysteine) codons in two synthetic polymers, poly(U-G) and ...
M J, Carrier, R H, Buckingham
openaire +2 more sources
Identification of the UUG codon as a translational initiation codon in vivo
Journal of Molecular Biology, 1975Abstract The lac repressor protein was purified from an Escherichia coli strain carrying an amber mutation in the lacI gene and the tyrosine-inserting amber suppressor, Su3. Protein sequencing showed a change at position 62 in the repressor polypeptide chain from leucine to tyrosine, proving that the amber was derived from a UUG codon at this ...
J G, Files +3 more
openaire +2 more sources
Codon bias from minimization of codon–anticodon interaction
Biosystems, 2016Inequalities between codon usage probabilities for quartets of codons are derived using a minimum principle for codon-anticodon interaction and a probability sum rule in the framework of the Crystal Basis Model of the genetic code. Performing this study separately for the Early and for the Eukaryotic Genetic Code, we observe a consistency in the ...
Sciarrino, Antonino, Sorba, Paul
openaire +3 more sources