Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng +18 more
wiley +1 more source
Analysis of Codon Usage Bias in the <i>Streptococcus pneumoniae</i> Pneumolysin Gene. [PDF]
Can J Infect Dis Med MicrobiolTan X +5 more
europepmc +1 more source
DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
G/C-ending and synonymous codon bias define functional translational programs that shape human tissue and cancer proteomes. [PDF]
NAR Genom BioinformRashad S, Niizuma K.
europepmc +1 more source
Advanced Science, EarlyView.CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan +12 more
wiley +1 more source
Mitochondrial Genome of <i>Abramis brama orientalis</i> Reveals Dominant Role of Natural Selection over Mutation Pressure in Shaping Codon Usage Bias in Leuciscinae Fishes. [PDF]
Animals (Basel)Hao CL +8 more
europepmc +1 more source
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, EarlyView.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source
Unraveling rare codon bias in Actinomycetota: lineage-specific and 5' terminal enrichment across 1936 genomes. [PDF]
BMC GenomicsRudenko A +6 more
europepmc +1 more source
The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus
Advanced Science, EarlyView.BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang +8 more
wiley +1 more source