Results 161 to 170 of about 494,112 (301)

Synonymous but not silent: functional codon bias reveals decoupled mitonuclear evolution in parasitic worms. [PDF]

Bioinform Adv
Das KC, Konhar R, Biswal DK.
europepmc   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Compensatory evolution facilitates loss of prfB autoregulation in Pseudomonas fluorescens SBW25. [PDF]

Mol Biol Evol
Lim S, Bertels F, Lopez-Garrido J, Gallie J.   +3 more
europepmc   +1 more source

Codon usage of highly expressed genes affects proteome-wide translation efficiency

Proceedings of the National Academy of Sciences of the United States of America, 2018
Idan Frumkin, M. Lajoie, Christopher J. Gregg, Gil Hornung, G. Church, Yitzhak Pilpel   +5 more
semanticscholar   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Extreme GC3 codon bias in a novel brown seaweed virus results in pseudoambigrammatic characteristics. [PDF]

Virus Evol
Dekker RJ, de Leeuw WC, Rauwerda H, van Olst MF, Ensink WA, van Leeuwen SM, Cohen J, Timmermans K, Breit TM, Jonker MJ.   +9 more
europepmc   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

The role of FMR1 mRNA structure on the efficiency of non-canonical translation of toxic polyglycine protein. [PDF]

Nucleic Acids Res
Niewiadomska D, Piasecka A, Baud A, Broniarek I, Sobczak K.   +4 more
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Lifestyle shapes genome architecture and codon usage bias in <i>Staphylococcus aureus</i> bacteriophages, suggesting stronger host adaptation in their virulent lineages. [PDF]

Front Microbiol
Gamkrelidze A, Janelidze D, Kobakhidze S, Elbakidze T, Kotetishvili M.   +4 more
europepmc   +1 more source