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Coenzyme Q10 in aging and disease
Critical reviews in food science and nutrition, 2022Coenzyme Q10 (CoQ10) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway.
Amin Gasmi +5 more
semanticscholar +1 more source
Pharmacokinetics of coenzyme Q10 [PDF]
Bulletin of Experimental Biology and Medicine, 2008 The pharmacokinetics of coenzyme Q10 powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q10 were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q10 exhibited high absorption creating higher plasma concentrations of the drug, as a ...
Medvedev Os +2 more
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Fetal Diagnosis and Therapy, 1996
Our objectives were to assess the plasma coenzyme Q10 (CoQ10) levels in normal pregnancy, in pregnancy with a spontaneous contractile event, in spontaneous abortion and in threatened abortion. Six hundred and fifteen CoQ10 levels were analyzed in 483 pregnant women: 350 patients were employed to design a normal curve; 66 patients with spontaneous ...
Noia, Giuseppe +6 more
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Our objectives were to assess the plasma coenzyme Q10 (CoQ10) levels in normal pregnancy, in pregnancy with a spontaneous contractile event, in spontaneous abortion and in threatened abortion. Six hundred and fifteen CoQ10 levels were analyzed in 483 pregnant women: 350 patients were employed to design a normal curve; 66 patients with spontaneous ...
Noia, Giuseppe +6 more
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Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations [PDF]
Mitochondrion, 2007 Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation.
Raj K. Chopra, Hemmi N. Bhagavan
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Coenzyme Q10 and male infertility
Journal of Endocrinological Investigation, 2009We had previously demonstrated that Coenzyme Q10 [(CoQ10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility).
Balercia, Giancarlo +7 more
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Coenzyme Q10 in essential hypertension
Molecular Aspects of Medicine, 1994This study was undertaken to clarify the mechanism of the antihypertensive effect of coenzyme Q10 (CoQ10). Twenty-six patients with essential arterial hypertension were treated with oral CoQ10, 50 mg twice daily for 10 weeks. Plasma CoQ10, serum total and high-density lipoprotein (HDL) cholesterol, and blood pressure were determined in all patients ...
DIGIESI V. +8 more
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Coenzyme Q10 for heart failure
Cochrane Database of Systematic Reviews, 2010Coenzyme Q10, or ubiquinone, is a non-prescription nutritional supplement. It is a fat-soluble molecule that acts as an electron carrier in mitochondria and as a coenzyme for mitochondrial enzymes. Coenzyme Q10 deficiency may be associated with a multitude of diseases including heart failure.
Yasser Shahrour +6 more
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Coenzyme Q10 for Parkinson's disease
Cochrane Database of Systematic Reviews, 2011A number of preclinical studies in both in vitro and in vivo models of Parkinson's disease have demonstrated that coenzyme Q10 can protect the nigrostriatal dopaminergic system. Some clinical trials have looked at the neuroprotective effects of coenzyme Q10 in patients with early and midstage Parkinson's disease.To assess the evidence from randomized ...
Siyan Zhan +3 more
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Coenzyme Q10 in atherosclerosis
European Journal of PharmacologyAtherosclerotic disease is a chronic disease that predominantly affects the elderly and is the most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to processes such as abnormal lipid transport and metabolism, impaired endothelial function, inflammation, and oxidative stress. Coenzyme Q10 (CoQ10) is a key component of
Minjun Liao +5 more
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2014
CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. CoQ10 deficiency has been associated with an enlarging spectrum of phenotypes (Table 56.1). Many patients had cerebellar ataxia, some had recurrent myoglobinuria with ragged-red fibers and lipid storage in muscle, and others had ...
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CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. CoQ10 deficiency has been associated with an enlarging spectrum of phenotypes (Table 56.1). Many patients had cerebellar ataxia, some had recurrent myoglobinuria with ragged-red fibers and lipid storage in muscle, and others had ...
openaire +4 more sources