Results 161 to 170 of about 519 (253)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

open access: yesPediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman   +7 more
wiley   +1 more source

Evaluating digital cognitive tests for clinical use in Alzheimer's disease: A novel framework and scoping review

open access: yesAlzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self‐administered digital cognitive assessments (SA‐DCAs) offer scalable approaches for early detection, yet their real‐world validation and clinical readiness ...
Harald Hampel   +10 more
wiley   +1 more source

Vulnerability of locus coeruleus connections to aging and Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer's disease (AD), remains unclear.
Blanca Zufiria‐Gerbolés   +9 more
wiley   +1 more source

Spatial‐Scale Evolutionary Bias Sheds Light on the Latitudinal Diversity Gradient

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
Using Escherichia coli as a model species, our experimental findings reveal that populations in high‐fitness‐gain geographic regions undergo rapid expansion, competitively excluding populations from low‐fitness‐gain regions. This results in adaptive evolution that is biased toward areas with higher fitness potential.
Haoyuan Wu, Donghui Xu, Yonghua Wu
wiley   +1 more source

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