Results 131 to 140 of about 4,970,070 (301)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Comparing the effectiveness of emotion-oriented therapy and cognitive-behavioral therapy on the action flexibility and psychological distress of women affected by infidelity

روانشناسی و روانپزشکی شناخت
Introduction: Marital infidelity results in significant psychological distress and a reduction in action flexibility. Therefore, therapeutic interventions aimed at enhancing action flexibility and alleviating psychological distress in women affected by ...
Leila Aghabalazadeh, Farnaz Farshbaf Manisefat, Ali Khademi   +2 more
doaj   +1 more source

Effectiveness of Cognitive-Behavioral Therapy on Depression, Anxiety, Negative Autonomic Thoughts, and Coping Strategies of Students [PDF]

Background and Aim: Students often struggle with multiple mental health issues, and there is a need for effective, short-term treatment. Cognitive behavioral therapy is one of the most effective and well-known treatment approaches. The present study aims
Golamikhah, Khadijeh, Abdolhosseini, Amir   +1 more
core   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Comparing effectiveness of cognitive behavioral therapy group and cognitive therapy based on mindfulness on life expectancy of dialysis patients [PDF]

مجله علوم روانشناختی
Background: Patients undergoing dialysis face numerous physical and psychological challenges that can affect their life expectancy. Among these, psychotherapeutic interventions such as cognitive-behavioral group therapy and mindfulness-based cognitive ...
Bahareh Hasani, Biuok Tajeri, Farahnaz Meschi, Alireza Shokrgozar, Nasrin Razavianzadeh   +4 more
doaj  

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

An investigation into the effects of cognitive behavioral therapy on patients with chronic depression: a small case series

, 2012
Gemma Louise HornUniversity of Dundee, Scotland, UKBackground: National Institute for Clinical Excellence (NICE) guidelines recommend a combination of cognitive behavioral therapy (CBT) and antidepressants to treat chronic depression.
Horn GL
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Effectiveness of online cognitive behavioral therapy on family caregivers of people with dementia

, 2014
Timothy Kwok,1,2 Alma Au,3 Bel Wong,1 Isaac Ip,1 Vivian Mak,1 Florence Ho11Jockey Club Centre for Positive Ageing, 2Department of Medicine and Therapeutics, Chinese University of Hong Kong; 3Department of Applied Social Sciences, Hong Kong Polytechnic ...
Kwok T, Ip I, Wong B, Mak V, Au A, Ho F
core