Results 81 to 90 of about 5,245,070 (303)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Cognitive behavioral group therapy versus psychoeducational intervention in Parkinson’s disease

, 2018
Isabella Berardelli,1 Maria Carmela Bloise,2 Matteo Bologna,2,3 Antonella Conte,2,3 Maurizio Pompili,1 Dorian A Lamis,4 Massimo Pasquini,2 Giovanni Fabbrini2,3 1Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center ...
Pasquini M, Pompili M, Bloise MC, Bologna M, Fabbrini G, Lamis DA, Conte A, Berardelli I   +7 more
core  

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Comparison of the effectiveness of acceptance and commitment-based therapy and positive cognitive-behavioral therapy on the pain self-efficacy of patients with chronic pain

مجله علوم روانشناختی, 2020
Background: Several studies have been conducted on the impact of acceptance-based and cognitive-behavioral therapy. But research comparing the efficacy of acceptance-based and commitment-based therapy and positive cognitive-behavioral therapy on pain ...
Siavash Kiani, Parviz Sabahi, Shahrokh Makvand Hosaini, Parvin Rafienia, MahmudReza Alebouyeh   +4 more
doaj  

Cognitive Behavioral Therapy for Adult Attention-Deficit Hyperactivity Disorder

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development, as characterized by symptoms of inattention and/or symptoms of ...
Safren, Steven A, Steven A. Safren, Susan E. Sprich, E. Sprich, Susan   +3 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Comparison between Cognitive-behavioral Therapy and Psychoeducational Therapy on Blood Sugar Control in Depressed Patients with Type 2 Diabetes

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Background and Objectives: Diabetes mellitus type 2 is an endocrine disease. Recently, it has been found that the risk of depression is nearly two fold in diabetic patients.
Maryam Palizgir, Maryam Bakhtiyari, Alireza Esteghamati   +2 more
doaj  

Basic theoretical foundations, essence and techniques of cognitive-behavioral therapy

, 2021
Today, cognitive-behavioral therapy methods and techniques are used extensively to solve psychological problems in adults. The use of these methods is also effective in eliminating cognitive and behavioral disorders in children and adolescents.
Ketevan Inasaridze
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source