Results 141 to 150 of about 691,530 (350)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Investigating the effectiveness of cognitive bias modification intervention and internet cognitive-behavioral therapy on food cravings in people applying for gastric bypass surgery [PDF]

open access: yesمجله علوم روانشناختی
Background: Although cognitive bias modification intervention and cognitive-behavioral therapy are two effective methods for reducing food cravings in obese people, to date, no randomized controlled trials compare the effectiveness of internet-based ...
samira tavakoli kohpaei   +2 more
doaj  

Internet Cognitive–Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial

open access: yesArthritis care & research, 2018
Kathleen O'Moore   +6 more
semanticscholar   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

open access: yesAdvanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai   +12 more
wiley   +1 more source

Corrigendum: Sensory Habituation as a Shared Mechanism for Sensory Over-Responsivity and Obsessive–Compulsive Symptoms

open access: yesFrontiers in Integrative Neuroscience, 2020
Tamar Y. Podoly   +2 more
doaj   +1 more source

Cognitive Behavioral Therapy as a Game Changer in HIV Prevention for Vulnerable Populations: A Systematic Review and Meta-Analysis [PDF]

open access: diamond
Hosam Awaji   +10 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

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