Results 231 to 240 of about 219,631 (310)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Effectiveness of cognitive behavioral therapy in improving symptoms of fatigue in patients with stroke and multiple sclerosis: a systematic review and meta-analysis. [PDF]

BMC Psychol
Wang S, Wang W, Wang N.
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Aligning large language models for cognitive behavioral therapy: a proof-of-concept study. [PDF]

Front Psychiatry
Kim Y, Choi CH, Cho S, Sohn JY, Kim BH.
europepmc   +1 more source

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Cognitive behavioral therapy for insomnia as a suicide prevention strategy: a protocol for a systematic review and meta-analysis. [PDF]

Sleep Adv
Türkmen C, Schneider CL, Furukawa Y, van Dalfsen JH, McCall WV, Pigeon WR, Tubbs AS, Perlis ML, Riemann D, Spiegelhalder K, Langsrud K, Kallestad H, Hertenstein E.   +12 more
europepmc   +1 more source

Empowering Flexible Electronics with Piezoelectric Nanogenerators: Breakthroughs from Energy Harvesting to Intelligent Sensing

Advanced Science, EarlyView.
This review systematically summarizes recent advances in self‐powered flexible sensing and energy storage systems based on piezoelectric nanogenerators (PENGs). It highlights their fundamental mechanisms, structural designs, and applications in health monitoring, e‐skin, and tactile sensing. The integration of PENGs with supercapacitors or batteries is
Wu‐Lin Xin, He‐Qing Cai, Xi Cui, Lu Han, Kou Zhang, Xin‐Yu Xue, Yi‐Fei Song, Juan Liu, Zhou Li   +8 more
wiley   +1 more source

The effectiveness of a multi-dimensional intervention model combining cognitive behavioral therapy and social support in hospitalized depressed patients. [PDF]

BMC Psychiatry
Liang Q, Xie G, Xu C, Li C, Liang J.
europepmc   +1 more source

Toward Advanced Degradable Soft Robotics Incorporating Transient Soft Electronics: Materials, Fabrication, and Applications

Advanced Electronic Materials, EarlyView.
Degradable soft robots are gaining attention for applications in various fields such as exploration, healthcare, and security. The integration of transient electronics is essential to enhance their intelligent task‐performing capabilities. This review offers insights into the advancement of soft electronic–robotic systems by providing an overview of ...
Kyung‐Sub Kim, Yong‐Joong Shin, Woo‐Jin Lee, Seung‐Kyun Kang   +3 more
wiley   +1 more source