Results 261 to 270 of about 1,059,442 (400)

Digital cognitive behavioral therapy as a novel treatment for insomnia. [PDF]

open access: yesWorld J Psychiatry
Tian XT   +9 more
europepmc   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

open access: yesAdvanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li   +9 more
wiley   +1 more source

Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications

open access: yesAdvanced Science, EarlyView.
This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue   +6 more
wiley   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

open access: yesAdvanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang   +21 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

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