Results 281 to 290 of about 965,316 (341)

CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease. [PDF]

Alzheimers Dement
Miners JS, Roy G, Love S, and for the Alzheimer's Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change. [PDF]

Alzheimers Res Ther
Richardson TE, Kandoi S, Almeida FC, Rohde SK, Marx GA, Canbeldek L, Hiya S, Maldonado-Díaz C, Samanamud J, Clare K, Slocum CC, Kulumani Mahadevan LS, Chiu LY, Farrell K, Crary JF, Daoud EV, White CL, Espinoza SE, Gonzales MM, Oliveira TG, Walker JM.   +20 more
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Selective Hippocampal Subfield Atrophy Mediates Cognitive Decline in Cushing's Disease. [PDF]

Brain Behav
Feng Z, Zhou T, Yan X, He K, Liu H, Yu X, Lu R, Ma Z, Yu X, Zhang Y.   +9 more
europepmc   +1 more source

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Advanced Science, EarlyView.
This study introduces a miniaturized wireless neural recording system integrated with custom‐designed 120‐channel µECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The system can capture and characterize behavior‐specific neural signals, including drinking‐related activation, pre‐vocalization anticipatory responses,
Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao, Xinjian Li, Mingjun Zhang   +22 more
wiley   +1 more source

Bidirectional relationships between disability and cognitive decline: a 6-year longitudinal study. [PDF]

BMC Geriatr
Hung TH, Wang TY, Chou HC, Chiu CJ, Lee CN, Tseng HH, Chen KC, Su YJ, Alberth A, Yang YK, Tsai TY.   +10 more
europepmc   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Inflammation and Cognitive Decline: A Population-Based Cohort Study Among Aging Adults With Atrial Fibrillation. [PDF]

J Am Heart Assoc
Marion D, Li Z, Roseborough A, Whitehead SN, Freeman EE, Birnie DH, Elahi FM, Hachinski V, Cushman M, Edwards JD.   +9 more
europepmc   +1 more source

LONGITUDINAL STUDIES OF COGNITIVE AGING: STUDY DESIGNS TO OPTIMIZE STATISTICAL POWER TO DETECT COGNITIVE DECLINE

Jasmin Duehring, L. L. Ong, Steven D. Edland   +2 more
openalex   +1 more source