Results 291 to 300 of about 965,316 (341)

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Subjective cognitive decline in individuals with isolated REM sleep behavior disorder. [PDF]

NPJ Parkinsons Dis
Ophey A, Röttgen S, Doppler CEJ, Scharfenberg D, Kufer K, Farrher E, Fink GR, Sommerauer M, Kalbe E.   +8 more
europepmc   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Synergistic effect between cortical cerebral microinfarcts and brain atrophy on cognitive decline. [PDF]

Brain
Huang J, Tan WY, Cui J, On SH, Chong EJY, Chen C, Hilal S.   +6 more
europepmc   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

White Matter Hyperintensities Impact Biomarker Prediction of Cognitive Decline

Bachmann D, Gericke C, Wybitul M, Saake A, Studer S, Rauen K, Gruber E, Buchmann A, Hullner M, Blennow K, Zetterberg H, Nitsch RM, Hock C, Treyer V, Gietl A.   +14 more
europepmc   +1 more source

Abnormal brain network reconfiguration in neuropsychiatric disorders across cognitive decline, Depression, and Schizophrenia. [PDF]

PLoS One
He Y, Yan Z, Liang Y, Yu Y.
europepmc   +1 more source

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Enzo Pereira de Lima, Masaru Tanaka, Caroline Barbalho Lamas, Karina Quesada, Cláudia Rucco Penteado Detregiachi, Adriano Cressoni Araújo, Élen Landgraf Guiguer, Virgínia Maria Cavallari Strozze Catharin, Marcela Vialogo Marques de Castro, Edgar Baldi, Bruna Fidêncio Rahal Ferraz, Vitor Cavallari Strozze Catharin, Lucas Fornari Laurindo, Sandra Maria Barbalho   +13 more
openalex   +2 more sources

Emergent neuropsychiatric symptoms as preclinical flags of cognitive decline: Clinical implications. [PDF]

Alzheimers Dement
Tang M, Yang M, Xie Y.
europepmc   +1 more source