Results 101 to 110 of about 3,242,957 (257)
BMC GeriatricsBackground This report examines how European geriatricians understand the concept of ‘cognitive frailty’, which was first formally defined by the International Academy on Nutrition and Aging (IANA) and the International Association of Gerontology and ...
Suzanne Timmons +12 more
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
COGNITIVE PROTOTYPE AS A DATA STRUCTURE FOR COGNITIVE STRUCTURES STORING
Medična Informatika ta Inženerìâ, 2016 The analysis of formal models of knowledge representaion in human minds allowed us to forge a definition of two new concepts: cognitive prototype (CP) as a processable and flexible data structure for representing models of cognitive structures (CS) in ...
O. A. Ryzhov, A. M. Popov
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration
NeuroImage: Clinical, 2018 Introduction: Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis.
L.E.M. Wisse +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
SCRIPTKELL : a tool for measuring cognitive effort and time processing in writing and other complex cognitive activities [PDF]
, 1999 We present SCRIPTKELL, a computer-assisted experimental tool that makes it possible to measure the time and cognitive effort allocated to the subprocesses of writing and other cognitive activities, SCRIPTKELL was designed to easily use and modulate ...
Roussey, JY +4 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Exploring Predictors of Cognitive Reserve and Cognitive Performance in Slovenia and in North Macedonia: The Effects of Survival versus Self-expression Values [PDF]
openCognitive reserve is a mechanism that enables maintenance of adequate cognitive abilities despite the presence of age or pathology induced brain changes.
MICEVSKA, MIA
core
Stylistyka, 2018 The subject of the article is the problem of describing the meaning of a word as a symbolic entity that is considered in the context of the requirements of modern lexicography.
Irena Szczepankowska
doaj +1 more source