Results 121 to 130 of about 1,204,653 (314)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Target-Specificity and repeatability in neuro-cardiac-guided TMS for heart-brain coupling

Translational Psychiatry
The dorsolateral prefrontal cortex (DLPFC) is a principal target for transcranial magnetic stimulation (TMS) in treating major depressive disorder, with therapeutic effects thought to be mediated by its connectivity with the subgenual anterior cingulate ...
Zi-Jian Feng, Sandra Martin, Ole Numssen, Konstantin Weise, Ying Jing, Gerasimos Gerardos, Carla Martin, Gesa Hartwigsen, Thomas R. Knösche   +8 more
doaj   +1 more source

Cognitive development as a piece of the language learning puzzle

, 2023
Why do children learn language more easily than adults do? This puzzle has fascinated cognitive and language scientists for decades. In the present letter, we approach the language learning puzzle from a cognitive perspective that is inspired by evidence
Smalle, EleonoreUGent0000804335118020026890579758911218140000-0003-2363-569313046570-F0EE-11E1-A9DE-61C894A0A6B4, Möttönen, Riikka   +1 more
core  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

A preliminary study on diagnosing learning difficulties in cell division topic for mGBL design and development

Social Sciences and Humanities Open
STEM education is crucial for equipping students with 21st-century skills to tackle modern challenges. Within STEM, Biology is often regarded as one of the most challenging subjects, with Cell Division being particularly difficult to learn.
Han-Cheng Low, Fitri Suraya Mohamad, Aazani Mujahid, Rehman Ullah Khan   +3 more
doaj   +1 more source

A longitudinal study of Turkish-Dutch children's language mixing in single-language settings: Language status, language proficiency, cognitive control and developmental language disorder [PDF]

The aim of this study was to investigate the role of language status, language proficiency, cognitive control and Developmental Language Disorder (DLD) in bilingual Turkish-Dutch children’s language mixing in single-language settings.
van Witteloostuijn, Merel, Yazıcı, Gülşah, Boerma, Tessel, Blom, Wilhelmina Bernardina T.   +3 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Conjunctive Visual and Auditory Development via Real-Time Dialogue

, 2003
Human developmental learning is capable of dealing with the dynamic visual world, speech-based dialogue, and their complex real-time association. However, the architecture that realizes this for robotic cognitive development has not been reported in the ...
Zhang, Yilu, Weng, Juyang
core  

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source