Abstract This randomized controlled trial examined the impact of The Connection Project, an experiential, relationship‐focused intervention designed to improve school belongingness and decrease symptoms of depression and loneliness among new college students.
Meghan A. Costello+6 more
wiley +1 more source
Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimerâs disease [PDF]
The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier+8 more
wiley +1 more source
Abstract GTF2IRD1, a gene on chromosome 7 which encodes a transcription factor, is of significant clinical interest due to its heterozygous loss as part of the classical deletion associated with Williams–Beuren syndrome (WBS). However, biallelic variants in GTF2IRD1 alone as part of an autosomal recessive disease have not been previously reported. Here,
Christopher Thomas Cummings+1 more
wiley +1 more source
Objectives To identify the prevalence and associated factors of cognitive dysfunction, 1 year after ICU discharge, among adult patients, and it´s relation with quality of life.
Isabel Jesus Pereira+12 more
doaj +1 more source
Visual Masking: A Reliable Measure for the Assessment of Cognitive Dysfunction in the Elderly? [PDF]
Thomas Schläpfer+3 more
openalex +1 more source
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
ABSTRACT Objectives Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status Scale (EDSS) scores, magnetic resonance imaging (MRI) lesion counts, and ...
Antonia Bralić+13 more
wiley +1 more source
Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy
Abstract Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11‐duplications detected in about 2%–3% of all patients.
Agneta Nordenskjöld+9 more
wiley +1 more source
Impact of Human Immunodeficiency Virus Type-1-Associated Cognitive Dysfunction on Activities of Daily Living and Quality of Life [PDF]
RHB Benedict+3 more
openalex +2 more sources
A Socio-Technical Grounded Theory on the Effect of Cognitive Dysfunctions in the Performance of Software Developers with ADHD and Autism [PDF]
The concept of neurodiversity, encompassing conditions such as Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), dyslexia, and dyspraxia, challenges traditional views of these neurodevelopmental variations as disorders and instead frames them as natural cognitive differences that contribute to unique ways of thinking and ...
arxiv