Results 151 to 160 of about 554,242 (284)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Sex differences in depression in Parkinson's disease: cognitive dysfunction and female-specific associations. [PDF]

Front Neurosci
Zhao H, Sun Y, Wang Q, Zhao Z.
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Fronto-cerebellar features associate with cognitive dysfunction in childhood-onset systemic lupus erythematosus. [PDF]

Semin Arthritis Rheum
Van der Heijden H, Alonzi G, Cao A, van Gool R, Yekedüz MK, Vrolix L, Ronen I, Rameh V, McBrearty K, Deokar A, Sundel RP, Muscal E, Gonzalez-Heydrich J, Knight A, Chang JC, Upadhyay J.   +15 more
europepmc   +1 more source

Marker associations of chronic heart failure severity and cognitive dysfunction in elderly patients

, 2023
V. N. Shishkova, В. А. Шишков, D. B. Ustarbekova   +2 more
openalex   +2 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy. [PDF]

CNS Neurosci Ther
Zhou Z, Yu X, Tian E, Guo Z, Chen J, Guo J, Shi S, Xu W, Zhai N, Qiao C, Zhang Y, Wang J, Lu Y, Zhang S.   +13 more
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Long COVID: lung pathophysiology and its relationship with cognitive dysfunction. [PDF]

Sci Rep
Staab KR, McIntosh MJ, Puliyakote ASK, Hahn AD, AlArab N, Percy JL, Lanning T, Theeler J, Linkenmeyer C, Wharff CJ, Bruening E, Sieren JC, Hoffman EA, Comellas AP, Hoth KF, Fain SB.   +15 more
europepmc   +1 more source

Postoperative cognitive dysfunction in the elderly surgical patient

, 1999
G Baer, Markku Paloheimo, T. Randell
openalex   +1 more source