Results 161 to 170 of about 552,457 (237)

A review of brain research on T2DM-related cognitive dysfunction. [PDF]

Open Med (Wars)
Liu Q, Dai S, Li X, Chen Y, Wang N, Wu J, Zhou Y, Yan B, Guo Y, Liu Y.   +9 more
europepmc   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: a systematic review and network meta-analysis. [PDF]

Front Aging Neurosci
Tu Y, Lu C, Wu B, Yang Y, Li J, Su Q, Zhao Z.   +6 more
europepmc   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Machine learning-based risk prediction model for cognitive dysfunction in elderly individuals. [PDF]

PLoS One
Zhang L, Xiang X, Chen W, Miao H, Zou T, Wu R, Zhou X.   +6 more
europepmc   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, EarlyView.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

Exercise interventions for sleep and cognitive dysfunction in shift workers: a systematic review of randomized trials. [PDF]

Front Public Health
Algharbi FH, Nuhmani S, Alsubaiei M, Shanb A, Alquaimi M.   +4 more
europepmc   +1 more source

Chinese Expert Consensus on Immune Checkpoint Inhibitor Therapy for Elderly Patients with Advanced Non‐small Cell Lung Cancer (2025 Edition)

AGING MEDICINE, EarlyView.
The literature screening process and the 78 included studies in this article comprise 11 retrospective analyses, 14 prospective studies targeting geriatric patients, 33 prospective studies containing elderly subgroup analyses, 7 cohort studies/others, and 13 review articles. ABSTRACT Immune checkpoint inhibitors (ICIs) are an important treatment option
National Center of Gerontology, Lung Cancer Committee of Beijing Oncology Association, Editorial Board of Chinese Journal of Geriatrics, Li Lin, Nie Xin, Wei Qian, Li Xu, Tian Yumeng, Wu Lin, Wang Jingyi, Wang Zhijie, Wang Mingzhao, Cao Baoshan, Gu Yangchun, Huang Meijuan, Yu Min, Yang Bo, Song Qi   +17 more
wiley   +1 more source

Understanding cognitive dysfunction in depression: perspectives and practices of UK health and social care professionals, a qualitative study. [PDF]

BMJ Open
Akhtar A, Nwofe E, Shafiq S, Parveen S, Windle K.   +4 more
europepmc   +1 more source