Results 171 to 180 of about 2,602,277 (303)

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage

Advanced Science, EarlyView.
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang   +10 more
wiley   +1 more source

Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass? [PDF]

, 2001
Stephen Westaby, Kjell Saatvedt, Samantha White, Takahiro Katsumata, Wim van Oeveren, Peter W. Halligan   +5 more
openalex   +1 more source

The Role of Hypertension in Cognitive Dysfunction

Journal of Clinical Medicine
Cognitive impairment and subsequent dementia are considered significant health challenges. In patients with established dementia, it is argued that hypertension is the main risk factor for small vessel ischemic disease and additional cortical white matter lesions.
Panagiotis Theofilis, Georgia Doumani, Georgia-Christina Tsatsani, Nikolaos Volis, Aikaterini Kampourelli, Vasileios Thimis, Eleni Xanthopoulou, Rigas Kalaitzidis   +7 more
openaire   +2 more sources

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Neurological disorders leading to mechanical dysfunction of the esophagus: an emergent behavior of a neuromechanical dynamical system [PDF]

arXiv
An understanding how neurological disorders lead to mechanical dysfunction of the esophagus requires knowledge of the neural circuit of the enteric nervous system. Historically, this has been elusive. Here, we present an empirically guided neural circuit for the esophagus.
arxiv  

Differential Age Effects of Mean Arterial Pressure and Rewarming on Cognitive Dysfunction After Cardiac Surgery

, 1995
Mark F. Newman, David Kramer, Narda D. Croughwell, Ian R. Sanderson, James A. Blumenthal, William D. White, Lloyd R. Smith, Elizabeth A. Towner, J. G. Rêves   +8 more
openalex   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Radiation-induced cognitive dysfunction: An experimental model in the old rat

, 1995
Ioannis Lamproglou, QI Ming Chen, G. Boisserie, Jean-Jacques Mazeron, M Poisson, F Baillet, Monique Le Poncin, Jean‐Yves Delattre   +7 more
openalex   +1 more source

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue

Advanced Science, EarlyView.
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao, Ben‐Chi Zhao, Hui‐Lin Li, Ying Liu, Bei Wang, An‐Qi Li, Tian‐Shu Zeng, Hannah Xiaoyan Hui, Jia Sun, Domagoj Cikes, Nele Gheldof, Jorg Hager, Jian‐Xun Mi, D. Ross Laybutt, Yin‐Yue Deng, Yan‐Chuan Shi, G. Gregory Neely, Qiao‐Ping Wang   +17 more
wiley   +1 more source

Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced delayed cognitive dysfunction in rats

, 1995
Shigeru Okuyama, Shinichi Ogawa, Atsuro Nakazato, K. Tomizawa   +3 more
openalex   +1 more source