Results 201 to 210 of about 554,242 (284)

Association of sarcopenic obesity with cognitive dysfunction and dementia: a systematic review and meta-analysis. [PDF]

Aging Clin Exp Res
Tang C, Song Y, Tao F, Hao J, Yan L, Shi X, Pei R, Zeng B.   +7 more
europepmc   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Diagnosis of Canine Cognitive Dysfunction Syndrome: A Narrative Review. [PDF]

Vet Sci
Vitturini C, Cerquetella M, Spaterna A, Bazzano M, Marchegiani A.   +4 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Assessment of Cognitive Dysfunction and Quality of Recovery after General Anesthesia in Perimenopausal Women.

J Pharm Bioallied Sci
Sinha D, Ekka N, Sharma NH, Shrivastava S.   +3 more
europepmc   +1 more source

MicroRNAs as biomarkers and molecular mediators of cognitive dysfunction in schizophrenia. [PDF]

J Neural Transm (Vienna)
Adly NM, Khalifa D, Abdel-Ghany S, Sabit H.   +3 more
europepmc   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Current practices for diagnosis and management of Canine Cognitive Dysfunction Syndrome in the United States. [PDF]

Front Vet Sci
Simon KE, Gruen ME, Olby NJ.
europepmc   +1 more source

GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders [PDF]

Hannah Hughes, Lillian J. Brady, Kirsten E. Schoonover   +2 more
openalex   +1 more source