Results 221 to 230 of about 554,242 (284)

Postoperative cognitive dysfunction: physiopathological aspects and clinical evidence

, 2019
Ghenadie Severin
openalex   +2 more sources

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Estrogen improves sevoflurane-induced cognitive dysfunction by regulating synaptic zinc homeostasis. [PDF]

Mol Med
Li F, Gong B, Yang T, Long S, Zhang J, Jiang Y, Yu Y, Yang Y, Li D.   +8 more
europepmc   +1 more source

Objective Cognitive Dysfunction Assessment in Patients with Subjective Cognitive Complaints: Does it Allow an Early Differentiation between Dementia and Mild Cognitive Impairment?

openalex   +1 more source

The Impact of General Anesthesia on Postoperative Cognitive Dysfunction Using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment–Indonesian Version (MOCA-Ina) in Geriatric Patients [PDF]

Farhana Mardila, Rr Sinta Irina, Dadik Wahyu Wijaya, Yuki Yunanda   +3 more
openalex   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Gut-Brain Axis and Perioperative Gut Microbiome in Postoperative Cognitive Dysfunction: Implications for Neurosurgical Patients. [PDF]

Med Sci (Basel)
Abdullah IA, Khan S, Hassan FE.
europepmc   +1 more source

Photobiomodulation for cognitive dysfunction (Brain Fog) in post-COVID-19 condition: a randomized double-blind sham-controlled pilot trial

Lew Lim, Nazanin Hosseinkhah, M van Buskirk, Kevin Oei, Andrea Berk, Abhiram Pushparaj, Janine Liburd, Zara Abbaspour, Jonathan Rubine, Jackson, David, Dr., Reza Zomorrodi   +10 more
openalex   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source