Results 241 to 250 of about 339,240 (318)

Cognitive Dysfunction in Unipolar Depression. [PDF]

open access: yesIndian J Psychol Med
Rakesh C, Sharma R, Singh C.
europepmc   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu   +6 more
wiley   +1 more source

Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy. [PDF]

open access: yesJ Neurol
Pasquini J   +11 more
europepmc   +1 more source

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li   +11 more
wiley   +1 more source

Early functional and structural hippocampal impairment in a bilateral common carotid artery stenosis mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Our study used behavioral tests, laser speckle flowmetry, long‐term potentiation, histochemical staining, molecular experiments, and voxel‐based morphometry to evaluate the hippocampal impairments. It demonstrates early functional and structural impairments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS ...
Ping Tang   +3 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam   +13 more
wiley   +1 more source

Cognitive dysfunction in Moyamoya disease: latest developments and future directions. [PDF]

open access: yesFront Hum Neurosci
Wang X   +6 more
europepmc   +1 more source

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