Results 241 to 250 of about 602,786 (295)

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment. [PDF]

Neurol Int
Phan E, Loo SP, Quinn TJ.
europepmc   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Suicidality among people with mild cognitive impairment: a sustematic review. [PDF]

BMC Psychiatry
Sánchez-Gil A, Pérez J, Navarro-López V, Sánchez-González JL.   +3 more
europepmc   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer's and related dementias. [PDF]

NPJ Dement
Rezaii N, Wong B, Aisen P, Beckett L, Dage JL, Eloyan A, Foroud T, Womack K, Carrillo MC, Kramer JH, Jack CR, Koeppe R, Kukull WA, Nudelman K, Polsinelli AJ, Raman R, Rumbaugh M, Taurone A, Thangarajah M, Toga A, Vemuri P, Atri A, Clark D, Day GS, Duara R, Graff-Radford NR, Grant I, Honig LS, Johnson ECB, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Scott Turner R, Wingo TS, Wolk DA, Hammers D, Kirby K, Rabinovici GD, Apostolova LG, Dickerson BC, LEADS Consortium.   +46 more
europepmc   +1 more source

CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park, Boyoung Kim, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon‐Seok Roh, Key‐Hwan Lim, Jin Tae Hong, Sang‐Bae Han, Chun‐Woong Park, Seok‐Beom Yong, Hanseul Park   +13 more
wiley   +1 more source

Evidence Summary of Management Strategies for Cognitive Impairment in Patients with Heart Failure. [PDF]

J Multidiscip Healthc
Ni F, Mi W, Wei Y, Li Z, Fan Y, Xi Z.
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source