Results 41 to 50 of about 2,422,569 (257)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Influence of cognitive neuroscience on contemporary philosophy of science

Translational Neuroscience, 2019
The study of contemporary philosophy of science based on cognitive neuroscience has strongly promoted the philosophy study of brain cognitive problems.
Ren Fang
doaj   +1 more source

Inconsistencies in atlas-based volumetric measures of the human nucleus basalis of Meynert: A need for high-resolution alternatives

NeuroImage, 2022
The nucleus basalis of Meynert (nbM) is the major source of cortical acetylcholine (ACh) and has been related to cognitive processes and to neurological disorders. However, spatially delineating the human nbM in MRI studies remains challenging.
Yawen Wang, Minye Zhan, Alard Roebroeck, Peter De Weerd, Sriranga Kashyap, Mark J. Roberts   +5 more
doaj   +1 more source

The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep ...
Yaser Norozpour, Mohammad Nasehi, Vahid Sabouri-Khanghah, Mohammad Nami, Salar Vaseghi, Mohammad-Reza Zarrindast   +5 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Hand preference for the visual and auditory modalities in humans

Scientific Reports, 2021
The sensory dominance effect refers to the phenomenon that one sensory modality more frequently receives preferential processing (and eventually dominates consciousness and behavior) over and above other modalities.
Yuqian Yang, Peter H. Weiss, Gereon R. Fink, Qi Chen   +3 more
doaj   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Erratum: Envisioning translational hyperscanning: how applied neuroscience might improve family-centered care (Social Cognitive and Affective Neuroscience (2022) (nsac061) DOI: 10.1093/scan/nsac061)

, 2023
This is a correction to: Elisa Roberti, Elena Capelli, Livio Provenzi Envisioning translational hyperscanning: how applied neuroscience might improve family-centered care, Social Cognitive and Affective Neuroscience, 2022; nsac061, https://doi.org/10 ...
Roberti E., Provenzi L., Capelli E.
core   +1 more source

Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity

Communications Psychology
Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3–8 Hz) activity ...
Max Kaiser, Yuejuan Wang, Sanne Ten Oever, Felix Duecker, Alexander T. Sack, Vincent van de Ven   +5 more
doaj   +1 more source

Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study

Scientific Reports, 2021
Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but while many therapeutic ...
Thomas M. H. Hope, Davide Nardo, Rachel Holland, Sasha Ondobaka, Haya Akkad, Cathy J. Price, Alexander P. Leff, Jenny Crinion   +7 more
doaj   +1 more source