Results 181 to 190 of about 26,574 (246)
La création de l’Institut des sciences cognitives du CNRS (1992-1998) [PDF]
, 2004 Marc Jeannerod
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Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease
Advanced Science, EarlyView.NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu +10 more
wiley +1 more source
Dynamiques de l’institutionnalisation sociale et cognitive des sciences de l’information
, 2002 Rosalba Palermiti, Yolla Polity
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Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain
Advanced Science, EarlyView.This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li +17 more
wiley +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
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Visual cognition from the standpoint of comparative cognitive science
, 2002 Masaki Tomonaga +2 more
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Applications of Artificial Intelligence in Drug Repurposing
Advanced Science, EarlyView.Artificial intelligence algorithms are transforming drug repurposing by revealing new therapeutic targets and mechanisms. This review highlights the integration of AI frameworks, multimodal datasets, and advanced optimization methods, accelerating the discovery of new indications for existing drugs.
Zhaoman Wan +6 more
wiley +1 more source
Implementing Goals for Non-cognitive Outcomes within a Basic Science Course
, 2002 Pamela L. Derstine
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Sequence Context‐Agnostic TadA‐Derived Cytosine Base Editors for Genome‐Wide Editing in Zebrafish
Advanced Science, EarlyView.zTadA‐CBEs, developed by introducing key mutations into TadA8e, enable efficient and precise sequence context‐agnostic cytosine base editing. Specifically, zTadA‐BE4max and zTadA‐BEmv provide complementary editing windows, while zTadA‐SpRY‐BE4max offers PAM‐flexible editing.
Shaohui Zheng +11 more
wiley +1 more source
On a new type of catastrophist representation for modelisation in biology and cognitive sciences
, 1997 Philippe Lacorre
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