Results 201 to 210 of about 26,574 (246)

Intertheory Relations in Cognitive Science: Privileged Levels and Reductive Strategies

, 2004
Jesús Ezquerro, Fernando Martínez Manrique   +1 more
openalex   +2 more sources

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, EarlyView.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

MICHÈLE KAIL ET MICHEL FAYOL, 2003 Les sciences cognitives et l'école2003, Paris, Presses Universitaires de France, 497 pages

, 2004
Alain Mercier
openalex   +2 more sources

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

Advanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang, Peng Qing, Qi Liu, Can Liu, Lei Liu, Xianyang Gan, Kun Fu, Chunmei Lan, Xinqi Zhou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao   +11 more
wiley   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Advanced Science, EarlyView.
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan, Yan Fang, Chuyun Lou, Nan Chen, Xuan Mo, Bo Jiao, Mengke Liu, Yangxi Zhao, Weichen Xu, Huixiong Xu, Haohao Yin, Yi Zhang   +11 more
wiley   +1 more source

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Advanced Science, EarlyView.
This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas   +4 more
wiley   +1 more source

Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome

Advanced Science, EarlyView.
A new CdCS rat model is developed using CRISPR‐Cas9 technology. It shows impairments in cognitive and social behaviors, neuronal dendrite abnormalities in the hippocampus and mPFC, and inflammatory and immune processes in mPFC brain cells. Early AAV‐Ctnnd2 gene therapy enhances cognitive function in CdCS rats.
Jingjing Shen, Yan Wang, Yang Liu, Junying Lan, Shuang Long, Yingbo Li, Di Chen, Peng Yu, Jing Zhao, Yongjun Wang, Shali Wang, Feng Yang   +11 more
wiley   +1 more source

Identification of Three Distinct Subgroups in Antiphospholipid Syndrome: Implication for Sex Differences and Prognostic Outcomes from a Multicenter Study

Advanced Science, EarlyView.
A large‐scale, multicenter, and two‐stage study is conducted to define antiphospholipid syndrome (APS) subgroups. By applying unsupervised K‐means clustering algorithm, the authors identified three distinct APS subgroups: obstetric APS, female thrombotic APS (tAPS), and male tAPS, which display marked differences in clinical manifestations and ...
Chen Chen, Ao Zhang, Jianhui Cheng, Zhongqiang Yao, Juan Meng, Yilu Qin, Qingyi Lu, Yufei Li, Xiangjun Liu, Tianhao Li, Chao Hou, Yundi Tang, Hongjiang Liu, Ning Xu, Sai Dong, Xinxin Li, Fangmin Xu, Jianping Guo, Chun Li   +18 more
wiley   +1 more source

Improving Adult Vision Through Pathway‐Specific Training in Augmented Reality

Advanced Science, EarlyView.
Traditional perceptual training approaches are limited by stimulus specificity, treatment efficacy, and patient compliance. A novel altered reality (AR) method is developed to enhance pathway‐specific functions in human adults while performing everyday activities.
Yige Gao, Yulian Zhou, Qing He, Wen Wen, Peng Zhang   +4 more
wiley   +1 more source