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Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo+10 more
wiley +1 more source
Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang+6 more
wiley +1 more source
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang+12 more
wiley +1 more source
Cognition, History and Science: Phenomena for the Cognitive Science of Science [PDF]
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Cognitive science as complexity science
WIREs Cognitive Science, 2020AbstractIt is uncontroversial to claim that cognitive science studies many complex phenomena. What is less acknowledged are the contradictions among many traditional commitments of its investigative approaches and the nature of cognitive systems. Consider, for example, methodological tensions that arise due to the fact that like most natural systems ...
Luis H. Favela
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Encyclopedia of Evolutionary Psychological Science, 2020
Derek Ream, Isaac Tourgeman
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Derek Ream, Isaac Tourgeman
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