Results 121 to 130 of about 580,232 (316)

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Maximizing Participation in Olfactory Training in a Sample with Post-COVID-19 Olfactory Loss

Brain Sciences
Purpose: This study aims to highlight the feasibility of an olfactory training program entirely monitored through online media in COVID-19 patients. Methods: Classic olfactory training was performed with a sample with olfactory loss due COVID-19 (n = 11).
Alice Helena Delgado-Lima, Jaime Bouhaben, María Luisa Delgado-Losada   +2 more
doaj   +1 more source

Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis

, 2009
BackgroundMultiple Sclerosis (MS) is an incurable, chronic, potentially progressive and unpredictable disease of the central nervous system. The disease produces a range of unpleasant and debilitating symptoms, which can have a profound impact including ...
McCrone Paul, Roche Suzanne, Dennison Laura, Sabine Landau, Moss-Morris, Rona, Trudie Chalder, Chalder, Trudie, Moss-Morris Rona, Lucy Yardley, Chalder Trudie, Roche, Suzanne, Yardley, Lucy, Suzanne Roche, McCrone, Paul, Yardley Lucy, Landau, Sabine; id_orcid, Chalder, Trudie; id_orcid, Landau, Sabine, Laura Dennison, Dennison, Laura, Paul McCrone, Landau Sabine, Rona Moss-Morris   +22 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Effect of Leisure Intervention on Occupational Performance and Occupational Balance in Individuals with Substance Use Disorder: A Pilot Study

Occupational Therapy International
Background and Purpose. Leisure, as an occupation, played a crucial role in promoting individuals’ health and well-being. However, the specific impact of leisure as an intervention for individuals with substance use disorder remains unclear.
Majid Farhadian, Malahat Akbarfahimi, Peyman Hassani Abharian, Mitra Khalafbeigi, Farzaneh Yazdani   +4 more
doaj   +1 more source

Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial

, 2010
Background: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis.
Andreas Bechdolf, Wölwer, Wolfgang, Buchkremer Gerhard, Klingberg, Stefan, Tilo Kircher, Bernhard W Müller, Engel Corinna, Bechdolf Andreas, Klingberg Stefan, Wagner Michael, Engel, Corinna, Buchkremer, Gerhard, Corinna Engel, Wittorf, Andreas, Meisner Christoph, Christoph Meisner, Sartory, Gudrun, Wiedemann, Georg, Michael Wagner, Müller, Bernhard W., Sartory Gudrun, Wagner, Michael, Meisner, Christoph, Stefan Klingberg, Georg Wiedemann, Wiedemann Georg, Herrlich Jutta, Wittorf Andreas, Jutta Herrlich, König Hans-Helmut, Herrlich, Jutta, Andreas Wittorf, Wolfgang Wölwer, König, Hans-Helmut, Bechdolf, Andreas, Kircher Tilo, Wölwer Wolfgang, Kircher, Tilo, Hans-Helmut König, Gerhard Buchkremer, Gudrun Sartory, Müller Bernhard W   +41 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Predictors of outcome in guided self-help cognitive behavioural therapy for common mental disorders in primary care

, 2020
Cognitive behavioural therapy (CBT) can effectively treat common mental disorders (CMDs), but access to treatment is insufficient. Guided self-help (GSH) CBT has shown effects comparable to face-to-face CBT and may be a resource-efficient treatment ...
Ljotsson, Brjann, Ejeby, Kersti, Hedman-Lagerlof, Erik, Salomonsson, Sigrid, Santoft, Fredrik, Lindsäter, Elin, Lekander, Mats,, Öst, Lars-Göran,, Ingvar, Martin   +8 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source