Results 241 to 250 of about 1,244,693 (357)

Effect of music therapy combined with cognitive restructuring therapy on emotional distress in a sample of Nigerian married couples

, 2018
Bernedeth N. Ezegbe, Moses Onyemaechi Ede, Chiedu Eseadi, Okechukwu O. Nwaubani, Immaculata Nwakaego Akaneme, Eucharia N. Aye, Kelechi R. Ede, Joachim C. Omeje, Chukwuemeka Alexander Ezurike, Charity N. Onyishi, Rifkatu Bulus Ali, Ngozi M. Eze, Grace Ngozi Omeje, Justina Ifeoma Ofuebe, Uchenna Cosmas Ugwu   +14 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

The influence of antipsychotic therapy on the cognitive functions of schizophrenic patients

, 2013
Piotr Tybura, Monika Mak, Agnieszka Samochowiec, Justyna Pełka-Wysiecka, Anna Grzywacz, Elżbieta Grochans, Liliana Zareba-Pechmann, Jerzy Samochowiec   +7 more
openalex   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Group-Delivered Mindfulness-Based Cognitive Therapy to Reduce Psychological Distress and Improve Sleep in Patients With Inflammatory Bowel Diseases: A Multicenter Randomized Controlled Trial (MindIBD). [PDF]

Inflamm Bowel Dis
Ter Avest MM, Huijbers MJ, Horjus CS, Römkens TEH, Witteman EM, van Dop WA, Dresler M, Donders ART, Dijkstra G, Nissen LHC, Speckens AEM.   +10 more
europepmc   +1 more source

Treating comorbid insomnia in patients enrolled in therapist-assisted transdiagnostic internet-delivered cognitive behaviour therapy for anxiety and depression: A randomized controlled trial

Michael Edmonds, Vanessa Peynenburg, Viktor Kaldo, Susanna Jernelöv, Nickolai Titov, Blake F. Dear, Heather D. Hadjistavropoulos   +6 more
openalex   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Mindfulness-based cognitive therapy for perceived stress and psychosomatic symptoms in Chinese adolescent girls: a mixed-methods school-based study of parent and teacher perceptions. [PDF]

BMC Psychol
Zhao Y.
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source