Results 101 to 110 of about 604,365 (299)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Relatedness, Coherence, and Coherence Dynamics Empirical Evidence from Italian Manufacturing [PDF]

This paper investigates the determinants of coherence and coherence change using a sample of Italian leading firms in the period 1993-1996. Following a methodology developed by Teece et al (1994), the observed diversification patterns of our sample firms
Davide Vannoni, Stefano Valvano
core  

SVM-based texture classification in optical coherence tomography [PDF]

, 2013
This paper describes a new method for automated textureclassification for glaucoma detection using high resolutionretinal Optical Coherence Tomography (OCT). OCT is anon-invasive technique that produces cross-sectional imageryof ocular tissue.
Alin Achim, James E Morgan, Anantrasirichai, N, Nicholson, Lindsay B, Achim, Alin M, Irina Erchova, N. Anantrasirichai, Morgan, James, Lindsay Nicholson, Erchova, Irina   +9 more
core   +1 more source

Complexity and Coherence [PDF]

Journal of the Society of Architectural Historians, 2012
Leslie Topp traces the emergence of the asylum mortuary as an architectural challenge. Drawing on new archival research, Complexity and Coherence: The Challenge of the Asylum Mortuary in Central Europe, 1898–1908 unpacks the highly fraught combination of scientific practices, death rituals, and psychiatric strategies that made up the mortuary's program.
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Men, Sport, Spinal Cord Injury and the Narrative Construction of Coherence [PDF]

, 2003
Drawing on data generated from a research project that focuses on the lived experiences of men who have experienced a spinal cord injury (SCI) through playing rugby football union, this chapter examines how a sense of coherence is constructed within ...
Smith, Brett, Sparkes, Andrew C.
core   +3 more sources

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Psychometric properties of the OLQ-13 scale to measure Sense of Coherence in a community-dwelling older population [PDF]

, 2011
Background With the ongoing demographic shift, the quality of life and health promotion among older individuals are becoming increasingly important. Recent research suggests that Sense of Coherence positively affects quality of life.
Vaandrager, L., Tobi Hilde, van den Esker Franciska, Hartog-van den Esker, F.G., den, Tobi, H., Jenneken Naaldenberg, Naaldenberg Jenneken, Vaandrager Lenneke, Lenneke Vaandrager, Franciska van den Esker, den Hartog-van den Esker, F.G., Naaldenberg, J., Hilde Tobi   +12 more
core   +1 more source