Results 41 to 50 of about 87,415 (264)
Coherent XUV Multispectral Diffraction Imaging in the Microscale
Applied Sciences, 2022 The rapid growth of nanotechnology has increased the need for fast nanoscale imaging. X-ray free electron laser (XFEL) facilities currently provide such coherent sources of directional and high-brilliance X-ray radiation.
Stylianos Petrakis +15 more
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Two-Point Resolution of a Defocused Imaging System Based on Spatially Coherent Illumination
PhotonicsWe examine the physical limitations and performance of spatially coherent imaging systems under defocused conditions using a modified two-point resolution criterion.
Gianlorenzo Massaro +4 more
doaj +1 more source
IEEE Photonics Journal, 2017 A scheme was proposed to achieve wide-field vibrational sum-frequency generation (SFG) microscopy with subdiffraction-limited resolution in one dimension. In this approach, samples are illuminated with a structured visible field and a uniform IR field to
Ya-Hui Li, Dan-Ni Chen, Han-Ben Niu
doaj +1 more source
Remote Sensing, 2023 Inverse synthetic aperture ladar (ISAL) can achieve high-resolution images for long-range moving targets, while its performance is affected by atmospheric turbulence.
Azezigul Abdukirim +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Potential of Attosecond Coherent Diffractive Imaging [PDF]
Physical Review Letters, 2020 14 pages, 4 ...
Arjun Rana +7 more
openaire +3 more sources
Pixel-Reassigned Spectral-Domain Optical Coherence Tomography
IEEE Photonics Journal, 2018 A novel method of pixel reassignment (PRA) is proposed to achieve transverse superresolution in the confocal microscopy. Inspired by it, for the first time, we report a pixel-reassigned spectral-domain optical coherence tomography (OCT) with $\sim$1.5 ...
En Bo +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source