Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
Why the ESPON Programme is concerned more with 'policy implications' than with 'good science'
European Journal of Spatial Development, 2007 Much of the European work undertaken on spatial planning has been carried out in the context of intergovernmental co-operation, which is not always promoted by the Commission.
Maria Prezioso
doaj +3 more sources
Improving the reliability of cohesion policy databases. [PDF]
PLoS One, 2022 Lo Piano S +5 more
europepmc +1 more source
Education, Equity and Social Cohesion : A Distributional Model [Wider Benefits of Learning Research Report No. 7] [PDF]
, 2003 This report - the first from the Centre’s comparative strand of research - focuses on the effects of education on social cohesion at the societal level. The research involved two elements.
Green, Andy +2 more
core +1 more source
Clickable Microgel Inks Enable Spatioselective, Multi‐Stimuli Programmable Assembly of Materials
Advanced Science, EarlyView.Clickable microgel inks enable direct ink writing of hydrogel architectures with intrinsic spatioselective and programmable multi‐responsiveness. By combining pH‐responsive and temperature‐responsive microgel building blocks through Diels‐Alder interparticle crosslinking, the assemblies exhibit controllable swelling and shape changes.
Junho Moon +3 more
wiley +1 more source
Should We Continue EU Cohesion Policy? The Dilemma of Uneven Development of Polish Regions. [PDF]
Soc Indic Res, 2023 Jagódka M, Snarska M.
europepmc +1 more source
The Future of EU Cohesion Policy. Endogenous Development – Added Value of Intervention – Regulatory Frameworks [PDF]
, 2012 The successful operation of the regional development – or cohesion – policy of the European Union has a strategic importance from the point of view of the whole integration process.
Kengyel, Ákos
core
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source