Results 101 to 110 of about 2,602,200 (268)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Trimester-specific association of maternal prenatal physical activities with risk of preterm birth: a prospective pre-birth cohort study

BMC Pregnancy and Childbirth
This study aimed to examine the trimester-specific association of maternal prenatal physical activities (PA) with risk of preterm birth (PTB). We recruited 2080 women during the first trimester and conducted follow-ups during the second and third ...
Jiajin Hu, Yanan Ma, Wenhan Jia, Ningyu Wan, Xiaochuan Wang, Lu Zheng, Zhe Yang, Dongming Zheng, Jun Wei, Deliang Wen   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health

Scientific Reports
Despite ferritin’s role in iron and metabolic health, its timing and pattern of change relative to other iron biomarkers during the menopausal transition remain unclear, as blood loss shifts alter iron metabolism.
Minjeong Kim, Yoosoo Chang, Yoosun Cho, Min-Jung Kwon, Hee-Kyung Joh, Ga-Young Lim, Ria Kwon, Jiin Ahn, Jungeun Park, Kye-Hyun Kim, Jae Keun Yoo, Seungho Ryu   +11 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Ambient temperature exposure during oocyte development and subsequent assisted reproductive outcomes: Potentially susceptible period and embryo-related intermediate pathway

Ecotoxicology and Environmental Safety
Ambient temperature is increasingly recognized as a climate-related environmental stressor with potential implications for human reproductive health; however, potentially susceptible exposure periods and intermediate pathways remain unclear.
Mengwen Yu, Hui Zhu, Jie Cai, Tao Chen, Chunhao Rong, Yiying Wu, Doudou Guo, Chongjing Chen, Yuxian Zhang, Luhui Pan, Lindan Ji, Jin Xu   +11 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cohort Profile: The Danish nurse cohort [PDF]

International Journal of Epidemiology, 2011
Hundrup, Yrsa A, Simonsen, Mette K, Jørgensen, Torben, Obel, Erik B   +3 more
openaire   +3 more sources

Cohort profile: The Nanjing Diabetes Cohort database – a population-based surveillance cohort

BMJ Open
Abstract Purpose To study epidemiology, complications, risk factors, clinical course and treatment patterns of diabetes, the Nanjing Diabetes Cohort (NDC) was established using anonymized electronic medical records from 650 hospitals and primary cares since 2020.
Wei Feng, Yuechuchu Yin, Chunyan Gu, Yuan Mu, Duxiao Zhang, Zhenhuan Tao, Weidong Yin, Xin Zhang, Yun Yu, Jie Hu, Cheng Wan, Yun Liu   +11 more
openaire   +3 more sources