Results 211 to 220 of about 45,541,444 (388)
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley +1 more source
Lipid profile in minor thalassemic patients: a historical cohort study
M Hashemieh+3 more
openalex +2 more sources
Living Habits and Personality Development of Adolescent Twins: A Longitudinal Follow-up Study in a Birth Cohort from Pregnancy to Adolescence [PDF]
I. Moilanen, Paula Rantakallio
openalex +1 more source
Cohort Profile: The Swiss HIV Cohort Study [PDF]
Swiss HIV Cohort Study,+9 more
openaire +4 more sources
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková+14 more
wiley +1 more source
Cohort study of the hypertensive effects of carbon disulfide in viscose rayon workers.
Haruhiko Sakurai, Yukio Seki
openalex +2 more sources
Correction: Risk of epilepsy after febrile convulsions: a national cohort study [PDF]
openalex +1 more source
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim+11 more
wiley +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source