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Engineered Coiled-Coil Protein Microfibers
Biomacromolecules, 2014The fabrication of de novo proteins able to self-assemble on the nano- to meso-length scales is critical in the development of protein-based biomaterials in nanotechnology and medicine. Here we report the design and characterization of a protein engineered coiled-coil that not only assembles into microfibers, but also can bind hydrophobic small ...
Jasmin, Hume +7 more
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Evidence That the Leucine Zipper Is a Coiled Coil
Science, 1989Recently, a hypothetical structure called a leucine zipper was proposed that defines a new class of DNA binding proteins. The common feature of these proteins is a region spanning approximately 30 amino acids that contains a periodic repeat of leucines every seven residues.
E K, O'Shea, R, Rutkowski, P S, Kim
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Predicting coiled-coil regions in proteins
Current Opinion in Structural Biology, 1997The past several years have seen significant advances in our ability to recognize coiled coils from protein sequences and model their structures. New methods include a detection program based on pairwise residue correlations, a program that distinguishes two-stranded from three-stranded coiled coils and a routine for modelling the coordinates of the ...
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Coiled-coils and fibrous proteins
Journal of Structural Biology, 2010David A D, Parry, John M, Squire
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Coiled-Coil Design: Updated and Upgraded
2017α-Helical coiled coils are ubiquitous protein-folding and protein-interaction domains in which two or more α-helical chains come together to form bundles. Through a combination of bioinformatics analysis of many thousands of natural coiled-coil sequences and structures, plus empirical protein engineering and design studies, there is now a deep ...
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Functional and Structural Roles of Coiled Coils
2017Coiled coils appear in countless structural contexts, as appendages to small proteins, as parts of multi-domain proteins, and as building blocks of filaments. Although their structure is unpretentious and their basic properties are understood in great detail, the spectrum of functional properties they provide in different proteins has become ...
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