Results 71 to 80 of about 603,566 (315)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Malaria and COVID-19 in Malarial Endemic Area: Incidence and Coincidence
Türkiye Parazitoloji Dergisi, 2022 Rujittika Mungmunpuntipantip +1 more
doaj +1 more source
Revista Cubana de Estomatología, 2011 Se realizó un estudio para determinar la proporción de concordancia entre los diagnósticos clínico e histopatológico de las biopsias estudiadas en el departamento de Patología Bucal de la Facultad de Odontología de la Universidad Autónoma de Nuevo León ...
Rogelio Sepúlveda Infante +1 more
doaj
Algebraic Coincidence Periods Of Self – Maps Of A Rational Exterior Space Of Rank 2
مجلة بغداد للعلوم, 2010 Let f and g be a self – maps of a rational exterior space . A natural number m is called a minimal coincidence period of maps f and g if f^m and g^m have a coincidence point which is not coincidence by any earlier iterates.
Baghdad Science Journal
doaj +1 more source
The Warrant Account and the Prominence of 'Know' [PDF]
, 2018 Many philosophers agree that there is an epistemic norm governing action. However, they disagree on what this norm is. It has been observed that the word ‘know’ is prominent in ordinary epistemic evaluations of actions. Any opponent of
Vollet, Jacques-Henri
core
Nonstabilized Nielsen coincidence invariants and Hopf--Ganea homomorphisms
, 2006 In classical fixed point and coincidence theory the notion of Nielsen numbers has proved to be extremely fruitful. We extend it to pairs (f_1,f_2) of maps between manifolds of arbitrary dimensions, using nonstabilized normal bordism theory as our main ...
Bogatyĭ +13 more
core +3 more sources
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source