Results 181 to 190 of about 35,198 (261)

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Coincidence of Autoimmune Diabetes Mellitus and Familial Partial Lipodystrophy. [PDF]

JCEM Case Rep
Krienke M, Schmidt HHJ, Buettner J, Tan S, Schumann I, Miehle K.   +5 more
europepmc   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

A data-driven approach for spatial alignment of PET add-on detectors with sub-millimeter accuracy. [PDF]

Phys Med Biol
Chen Y, Cai L, Komarov S, O'Sullivan JA, Tai YC.   +4 more
europepmc   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Tracking the Complex Dynamics of Electron-Transfer-Mediated Decay in Real Space and Time. [PDF]

J Am Chem Soc
Trinter F, Hofierka J, Rist J, Kircher M, Weller M, Melzer N, Tsitsonis D, Geyer A, Kruse J, Kastirke G, Williams JB, Miteva T, Dörner R, Schöffler MS, Kunitski M, Sisourat N, Cederbaum LS, Jahnke T.   +17 more
europepmc   +1 more source

Two Material Properties from One Wavelength‐Orthogonal Photoresin Enabled by a Monochromatic Laser Integrated Stereolithographic Apparatus (Mono LISA)

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A single object with dual properties – degradable and non‐degradable – is fabricated in a single print simply by switching the printing colors. The advanced multi‐material printing is enabled by the combination of a fully wavelength‐orthogonal photoresin and a monochromatic tunable laser printer, paving the way for precise multi‐material ...
Xingyu Wu, Katharina Ehrmann, Ching Thye Gan, Benjamin Leuschel, Fred Pashley‐Johnson, Christopher Barner‐Kowollik   +5 more
wiley   +1 more source

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels. [PDF]

J Physiol
Herrera GM, Rengo JL, Hennig GW, Heppner TJ, Hepp AM, Sancho M, Huerta de la Cruz S, Nelson MT, Klug NR.   +8 more
europepmc   +1 more source

Unveiling the Role of Curvature in Carbon for Improved Energy Release of Ammonium Perchlorate

Advanced Materials, EarlyView.
High‐curvature carbon materials identified via machine learning and simulation can enhance the heat release and combustion performance of ammonium perchlorate. ABSTRACT The catalytic role of carbon curvature in the thermal decomposition of ammonium perchlorate (AP) remains largely unexplored. To address this gap, this study employs machine learning and
Dan Liu, Keliang Song, Haorui Zhang, Zhipeng Liu, Guansong He, Junru Wang, Wenming Yang, Xu Zhao, Zhijian Yang   +8 more
wiley   +1 more source

Beyond mechanics: Maximum-likelihood-driven PET detector alignment calibration. [PDF]

Med Phys
Thull J, Kuhl Y, Mueller F, Schug D, Weissler B, Schulz V.   +5 more
europepmc   +1 more source