FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Consensual Coitus Leading to Vaginal Perforation, Bowel Evisceration, and Hemorrhagic Shock: A Report of a Rare Case. [PDF]
CureusHoumaid H +4 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Seminal fluid effects on female reproductive function in laboratory, livestock, and domestic species. [PDF]
J Reprod DevChan HY, Schjenken JE, Robertson SA.
europepmc +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Prevalence and attributes of cervicovaginal human papillomavirus infection among a 35-year- age- cohort of ever-married women in a district of Sri Lanka: a cross-sectional study. [PDF]
BMC MedPerera KCM, Mapitigama N, Abeysena HTCS.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women. [PDF]
Front Endocrinol (Lausanne)Sulu C +12 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Evaluation of ChatGPT Responses About Sexual Activity After Total Hip Arthroplasty: A Comparative Study with Observers of Different Experience Levels. [PDF]
J Clin MedGencer B +4 more
europepmc +1 more source