Results 181 to 190 of about 11,007 (260)

STI knowledge and risk behaviors among university students in northeastern Italy: the role of medical education and sexual experience. [PDF]

Front Public Health
Tocco Tussardi I, Cazzoletti L, Busch IM, Poli S, Benoni R, Rimondini M, Tardivo S, Moretti F.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Patterns of Different Cervical Cytokine Expression in High-Risk Human Papillomavirus-Infected Patients With Cervical Cancer and Its Precancerous Lesions. [PDF]

Clin Med Insights Oncol
Saha S, Sultana S, Rahmat R, Akther T, Nessa A, Jahan M.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Knowledge and attitude of deaf women in relation to contraceptive methods: A systematic review. [PDF]

Clinics (Sao Paulo)
Barbosa GF, Ferreira-Filho ES, Quintão LA, Berto LF, de Almeida PG, Baracat EC, Bahamondes L, Soares-Junior JM, Sorpreso ICE.   +8 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A new scoring system to predict the success of single-dose methotrexate therapy in ectopic pregnancy. [PDF]

Rev Assoc Med Bras (1992)
Kale İ, Yalçınkaya C, Konak G, Zengin A.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evisceration of Abdominal Contents Through a Posterior Vaginal Defect: A Case Report. [PDF]

Case Rep Obstet Gynecol
Nguyen E, Ferraro J, Galvan-Turner V, Emeruwa I.   +3 more
europepmc   +1 more source