Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 [PDF]
Discover OncologyBackground Cancer-associated fibroblasts (CAFs) are key components of tumor microenvironment and have been identified to be involved in modulating drug resistance in cancers by secreting molecules.
Rongyu Shi +6 more
exaly +4 more sources
Identifying six single nucleotide variants in the COL17A1 gene that alter RNA splicing: database analysis and minigene assays [PDF]
Scientific ReportsCollagen type XVII alpha 1 chain (COL17A1) is a protein in the collagen family crucial for maintaining the integrity of skin and epithelial tissues. It is also vital for enamel formation and plays a significant role in the differentiation of ameloblasts.
Yingfei Shao, Ran Zhang
exaly +4 more sources
Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin [PDF]
Advanced ScienceThe layered structure of skin necessitates highly sophisticated tissue coordination during regeneration. The unmet clinical need of long‐term skin expansion therapy stems from limited regenerative capacity, yet the underlying mechanism remains enigmatic ...
Yidan Sun +13 more
doaj +3 more sources
Association of immune checkpoint inhibitor-induced bullous pemphigoid with underlying cancer type: A lack of association with cancer tissue COL17A1 mutations and dysregulation [PDF]
JID InnovationsBullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 (COL17A1) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs).
Rachel C. Chang +10 more
doaj +3 more sources
The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression
Clinical Respiratory JournalBackground Lung adenocarcinoma (LUAD) is a highly aggressive and rapidly fatal malignancy worldwide. Collagen XVII (COL17A1) has been implicated in various protumorigenic processes.
Huifeng Li
exaly +3 more sources
COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa
Frontiers in Medicine, 2022 BackgroundEpidermolysis bullosa (EB), a severe genetic disorder characterized by blister formation in skin, is caused by mutations in genes encoding dermal-epidermal junction proteins that function to hold the skin layers together.
Julia Reichelt +2 more
exaly +4 more sources
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1
Cell ReportsSummary: Deficiency of DNA repair pathways drives the development of colorectal cancer. However, the role of the base excision repair (BER) pathway in colorectal cancer initiation remains unclear.
Jin-Long Lin
exaly +4 more sources
Morphological abnormalities in the ureter of type XVII collagen–deficient mice [PDF]
Scientific ReportsNon-fibrillar type XVII collagen (COL17A1) is a hemidesmosomal component of the epidermis and a key skin-disease molecule. We previously reported that COL17A1 is expressed in the urothelium of multiple species at low constitutive or in inducible levels ...
Amy Suzui +8 more
doaj +2 more sources
Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway [PDF]
Frontiers in Cell and Developmental BiologyBackgroundHair follicle aging is driven by COL17A1 proteolysis in hair follicle stem cells (HFSCs). Mesenchymal stem cell (MSC)-derived exosomes show promise in tissue regeneration, but their effects on COL17A1 and hair follicle aging remain unexplored ...
Shiyue Cui +4 more
doaj +2 more sources
BMC Medical Genomics, 2022 Background Uniparental disomy (UPD) is a condition in which both chromosomes are inherited from the same parent, except for imprinting disorders. Uniparental isodisomy (UPiD) may result in a homozygous variant contributing to an autosomal recessive ...
Yao Wang +11 more
doaj +3 more sources