Results 81 to 90 of about 2,525,206 (182)

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

Identification of Subtype-Specific Three-Gene Signature for Prognostic Prediction in Diffuse Type Gastric Cancer

Frontiers in Oncology, 2019
Gastric cancer (GC), with high heterogeneity, can be mainly classified into intestinal type and diffuse type according to the Lauren classification system.
Bowen Bao, Bowen Bao, Bowen Bao, Chunlei Zheng, Chunlei Zheng, Chunlei Zheng, Bowen Yang, Bowen Yang, Bowen Yang, Yue Jin, Yue Jin, Yue Jin, Kezuo Hou, Kezuo Hou, Kezuo Hou, Zhi Li, Zhi Li, Zhi Li, Xueying Zheng, Xueying Zheng, Xueying Zheng, Shitong Yu, Shitong Yu, Shitong Yu, Xiaojie Zhang, Xiaojie Zhang, Xiaojie Zhang, Yibo Fan, Yibo Fan, Yibo Fan, Xiujuan Qu, Xiujuan Qu, Xiujuan Qu, Yunpeng Liu, Yunpeng Liu, Yunpeng Liu, Xiaofang Che, Xiaofang Che, Xiaofang Che   +38 more
doaj   +1 more source

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Low frequency of parental mosaicism in de novo COL4A5 mutations in X‐linked Alport syndrome

Molecular Genetics & Genomic Medicine, 2020
Background Alport syndrome is a progressive hereditary kidney disease clinically presenting with haematuria, proteinuria, and early onset end‐stage renal disease, and often accompanied by hearing loss and ocular abnormalities. The inheritance is X‐linked
Ole Magnus Bjorgaas Helle, Torkild Høieggen Pedersen, Lilian Bomme Ousager, Mads Thomassen, Jens Michael Hertz   +4 more
doaj   +1 more source

De novo mutation in the COL4A5 gene converting glycine 325 to glutamic acid in Alport syndrome

, 1992
Southern blot analysis of the COL4A5 gene in a 6 year old Italian Alport patient (proband VIZ) showed the loss of an MspI site that was present in the mother and control DNAs. PCR amplification and DNA sequencing revealed a single G-->A nucleotide change.
SERI M., RENIERI A., RIZZONI G., DE MARCHI M., MYERS J. C., PIHLAJANIEMI T., MASSELLA L.   +6 more
core   +1 more source

Identification of novel COL4A5 variants and prenatal diagnosis in three large families

Scientific Reports
Alport syndrome (AS) is the second-most frequent monogenic kidney disease and 85% of cases are caused by mutations in the genes of the α5 chains of collagen type IV (COL4A5). The early diagnosis and treatment are essential for the prognosis of AS.
Baitao Zeng, Yao Yu, Cong Liu, Xinyu Li, Qing Lu, Zhongfa Chen, Jia Chen, Jun Zou, Bicheng Yang, Yanqiu Liu, Yongyi Zou   +10 more
doaj   +1 more source

Table_2_Clinical Manifestations of Alport Syndrome-Diffuse Leiomyomatosis Patients With Contiguous Gene Deletions in COL4A6 and COL4A5.XLSX

, 2021
Alport syndrome-diffuse leiomyomatosis is a rare type of X-linked Alport syndrome resulting from contiguous deletions of 5′ exons of COL4A5 and COL4A6.
Xi Zhou (452148), Jingjing Wang (140791), Qing Ye (90197), Jianhua Mao (447450)   +3 more
core   +1 more source

Alport’s Syndrome

Turkish Journal of Nephrology, 2019
Alport’s syndrome is a hereditary kidney disease, frequently associated with hearing loss and ocular abnormalities. Type IV collagen is the main constituent of the basement membranes.
Tayfun AKALIN, M. Deniz AYLI, Ekrem ABAYLI   +2 more
doaj  

Table_4_Clinical Manifestations of Alport Syndrome-Diffuse Leiomyomatosis Patients With Contiguous Gene Deletions in COL4A6 and COL4A5.DOCX

, 2021
Alport syndrome-diffuse leiomyomatosis is a rare type of X-linked Alport syndrome resulting from contiguous deletions of 5′ exons of COL4A5 and COL4A6.
Xi Zhou (452148), Jingjing Wang (140791), Qing Ye (90197), Jianhua Mao (447450)   +3 more
core   +1 more source